X. Edward Guo

Professor of Biomedical Engineering
Vice Chair, Department of Biomedical Engineering

351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904
New York, NY 10027

Phone: +1 212-854-6196
Fax: +1 212-854-8725
Email: exg1@columbia.edu

Research Areas:

Image based microstructural and finite element analyses of skeletons; in vitro mechanobiology of osteocytes, osteoblasts, and osteoclasts; and 3D cell mechanics and mechanotransduction.

Bone Bioengineering Lab

Education

  • 1984: B.S., Applied Mechanics/Biomechanics, Peking University
  • 1990: M.S., Mechanical Engineering/Medical Engineering, Harvard University
  • 1994: Ph.D., Medical Physics/Medical Engineering, Harvard–MIT Division of Health Sciences and Technology
  • 1993-96: Post-doctoral Training in Musculoskeletal Bioengineering, University of Michigan

Research Interests

  • µCT, µMRI, and HR-pQCT Image Analysis of Bone Microstructure
  • Novel Image Based Microstructural and FE Analyses of Osteoporosis Patients
  • Mechanobiology of 3D In Vitro Trabecular Bone Explants
  • Mechanotransduction in Osteocyte Network
  • Single Osteocyte Cell Mechanics

 

Publications (Since 2000)

  • Guo, X. E. and Goldstein, S. A. (2000) Vertebral Trabecular Bone Microscopic Tissue Elastic Modulus and Hardness Do Not Change in Ovarietomized Rats, J. Orthop. Res., 18(2): 333-336.
  • Schaffner, G., Guo, XD. E., Silva, M. J. and Gibson, L. J. (2000) Modeling Fatigue Damage Accumulation in Two-Dimensional Voronoi Honeycombs, Intl. J. Mech. Sci., 42(4): 645-656.
  • Guo, X. E., and Kim, C. H. (2002) Mechanical Consequence of Trabecular Bone Loss and Its Treatment: A Three-Dimensional Model Stimulation, Bone, 30(2): 404-411.
  • Guo, X. E.,Eichler, M. J., Takai, E. and Kim, C. H. (2002) A Rat Tail Vertebrae Model for Trabecular Bone Adaptation Studies, J. Biomech. 35(3): 363-368.
  • Lai, W. M., Sun, D. D., Ateshian, G. A., Guo, X. E., and Mow, V. M. (2002) Electrical Signals for Chondrocytes in Cartilage, Biorheology, 39(1/2): 11-25.
  • Wang, C. C., Guo, X. E., Sun, D., Mow, V. C., Ateshian, G. A., and Hung, C. T. (2002) The Functional Environment of Chondrocytes within Cartilage Subjected to Compressive Loading: Theoretical and Experimental Approach, Biorheology, 39(1/2): 39-45.
  • Mow, V. C. and Guo, X. E. (2002) Mechano-Electrochemical Properties of Articular Cartilage: Their Inhomogeneities and Anisotropies, Annual Review in Biomedical Engineering, 4:175-209.
  • Kim, C. H., Takai, E., Zhou, H., von Stechow, D., Müller, R., Dempster, D. W., and Guo, X. E. (2003)Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironments, J. Bone and Miner. Res., 18(12): 2116-2125.
  • Hung, C. T., Lima, E G., Mauck, R. L., Takai, E., LeRoux, M. A., Lu, H. H., Stark, R. G., Guo, X. E., and Ateshian, G. A. (2003) Anatomically Shaped Osteochondral Constructs for Articular Cartilage Repair, J. Biomemch., 36(12):1853-1864.
  • Chua, S. C. Jr., Liu, S. M., Li, Q., Sun, A., DeNino, W. F., Heymsfield, S. B., and Guo, X. E. (2004) Transgenic Complementation of Leptin Receptor Deficiency. II. Increased Leptin Receptor Transgene Dose Effects on Obesity/diabetes and Fertility/lactation in Lepr-db/db mice, Am. J. Physiol. Endocrinol. Metab.,286(3):E384-392.
  • Sun, D. D., Guo, X. E., Likhitpanichkul, M., Lai, W. M., and Mow, V.C. (2004) The Influence of the Fixed Negative Charges on Mechanical and Electrical Behaviors of Articular Cartilage under Unconfined Compression, ASME J Biomech. Eng., 126(1):6-16.
  • Lu, X. L., Sun, D. D., Guo, X. E., Chen, F. H., Lai, W. M., and Mow, V. C. (2004) Indentation Determined Mechanoelectrochemical Properties and Fixed Charge Density of Articular Cartilage, Ann. Biomed. Eng. 32(3): 370-379.
  • Wan, L. Q., Miller, C., Guo, X. E., and Mow, V. C. (2004) Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm, Mechanics and Chemistry of Biosystems, 1(1):81-99.
  • Dong, X. N. and Guo, X. E. (2004) The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity, J. Biomech., 37:1281-2187.
  • Takai, E., Mauck, R. L., Hung, C. T. and Guo, X. E. (2004) Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant under Dynamic Hydrostatic Pressure, Journal of Bone and Mineral Research, 19(9):1403-1410.
  • Dong, X. N. and Guo, X. E.  (2004) Geometric Determinants to Cement Line Debonding and Osteonal Lamellae Failure in Osteon Pushout Tests, ASME J. Biomech. Eng., 126(3):387-390.
  • Dong, X. N., Zhang, X. H., Huang, Y. Y., and Guo, X. E. (2005) A Generalized Self-consistent Estimate for the Effective Elastic Moduli of Fiber-reinforced Composite Materials with Multiple Transversely Isotropic Inclusions, Int. J. Mech. Sc., 47(6): 922–940.
  • Takai, E., Costa, K. D., Shaheen, A., Hung, C. T., and Guo, X. E. (2005) Osteoblast Elastic Modulus Measured by Atomic Force Microscopy is Substrate Dependent, Annals of Biomedical Engineering, 33(7):963–971. (Cover Picture)
  • Dong, X. N., Zhang, X., and Guo, X. E. (2005) Interfacial Strength of Cement Lines in Human Cortical Bone, Mechanics and Chemistry of Biosystems, 2(2):63-68.
  • Lu, H. H., Jiang, J., Tang, A., Hung, C. T., and Guo, X. E. (2005) Development of Controlled Heterogeneityy on a Polymer-Ceramic Hydrogel Scaffold for Osteocondral Repair, Key Engineering Materials, 284-286:607-610.
  • Xu, X. L., Tang, T., Dai, K., Zhu, Z., Guo, X. E., Yu, C., Lou, J. (2005) Immune Response and Effect of Adenovirus-mediated Human BMP-2 Gene Transfer on the Repair of Segmental Tibial Bone Defects in Goats, Acta Orthopaedica, 76(5):637-646.
  • Hoffler, C. E., Guo, X. E., Zysset, P. K., and Goldstein, S. A. (2005) An Application of Nanoindentation Technique to Measure Bone Tissue Lamellae Properties,ASME J. Biomech. Eng., 127(7):1046-1053.
  • Likhitpanichkul, M., Guo, X. E., and Mow, V. C. (2005) The Effect of Matrix Tension-Comprression Nonlinearity and Fixed Charges on Chondrocyte Response in Cartilage, Molecular and Cellular Biomechanics, 2(4):191-204.
  • Takai, E., Landersberg, R., Katz, R. W., Hung, C. T., and Guo, X. E. (2006) Substrate modulation of Osteoblast Cell Adhesion Strength, Focal Adhesion Kinase Activation, and Responsiveness to Mechanical Stimuli, Molecular and Cellular Biomechanics, 3(1):1-12.
  • Dong, X. N., and Guo, X. E. (2006) Prediction of Cortical Bone Elastic Constants by A Two-Level Micromechanical Model Using A Generalized Self-Consistent Method, ASME Journal of Biomechanical Engineering, 128(3):309-316.
  • Ishii, Y., Thomas, A. O., Guo, X. E., Hung, C. T., and Chen, F. H. (2006) Localization and Distribution of Cartilage Oligomeric Matrix Protein in the Rat Intervertebral Disc, Spine, 31(14): 1539-1546.
  • Ho, M. M., Kelly, T. A., Guo, X. E., Ateshian, G. A., and Hung, C. T. (2006) Spatially Varying Material Properties of the Rat Caudal Intervertebral Disc, Spine, 31(15): E486-493.
  • Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., and Guo, X. E. (2006) Quantification of the Roles of Trabecular Microarchitecture and Trabecular Type in Determining the Elastic Modulus of Human Trabecular Bone, Journal of Bone and Mineral Research, 21(10):1608-1617.
  • Guo, X. E., Takai, E., Jiang, X., Xu, Q., Whitesides, G. M., Yardley, J. T., Hung, C. T., Chow, E. M., Hantschel, T., and Costa, K. D. (2006) Intracellular Calcium Waves in Bone Cell Networks Under Single Cell Nanoindentation, Molecular and Cellular Biomechanics, 3(3):95-107.
  •  Freed, L. E., Guilak, F., Guo, X. E., Gray, M. L., Tranquillo, R., Holmes, J. W., Radisic, M., Sefton, M. V., Kaplan, D., and Vunjak-Novakovic, G. (2006) Advanced Tools for Tissue Engineering: Scaffolds, Bioreactors, and Signaling, Tissue Engineering, 12(12):3285-3305.
  • Lu, X. L., Miller, C., Chen, F. H., Guo, X. E., and Van C. Mow (2007) The Generalized Triphasic Correspondence Principle for Simultaneous Determination of the Mechanical Properties and Proteoglycan Content of Articular Cartilage by Indentation, Journal of Biomechanics, 40(11):2434-2441.
  • Kim, C. H., Zhang, X. H., Mikhail, G. von Stechow, D., Müller, R. Kim, H. S., and Guo, X. E. (2007) Effects of Thresholding Techniques on mnicro-CT Based Finite Element Models of Trabecular Bone, ASME Journal of Biomechanical Engineering, 129(4):481-486.
  • Sigmund, E. E., Cho, H., Chen, P., Byrnes, S., Song, Y. Q., Guo, X. E., and Brown, T. R. (2008) Diffusion-based MR Methods for Bone Structure and Evolution, Magnetic Resonance in Medicine, 59(1):28–39.
  • Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., Bevil, G., Keaveny, T. M., and Guo, X. E. (2008) Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations with Anisotropic Elastic Moduli in Human Trabecular Bone, Journal of Bone Mineral Research, 23(2):223-235.
  • Huo B., Lu, X. L., Hung, C. T., Costa, K. D., Xu, Q., Whitesides, G. M., and Guo, X. E. (2008) Fluid Flow Induced Calcium Response in Bone Cell Network, Cellular and Molecular Bioengineering, 1(1):58-66. (Cover Picture)
  • Wan, L. Q., Jiang, J., Arnold, D. E., Guo, X. E., Lu, H. H., and Mow, V. C. (2008) Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs, Cellular and Molecular Bioengineering, 1(1): 93-102.
  • Zhang, X. H., Liu, X. S., Vasilic, B., Wehrli, F. W., Benito, M., Rajapakse, C. S., Snyder, P. J., and Guo, X. E. (2008) In Vivo µMRI-Based Finite Element and Morphological Analyses of Tibial Trabecular Bone in Eugonadal and Hypogonadal Men before and after Testosterone Treatment, Journal of Bone Mineral Research, 23(9): 1426-1434.
  • Spalazzi, J. P., Dagher, E., Soty, S. B., Guo, X. E., Rodeo, S. A., and Lu, H. H. (2008) In Vivo Evaluation of A Multi-phased scaffold designed for Orthopaedic Interface Tissue Engineering and Soft Tissue-to-Bone Integration, Journal of Biomedical Materials Research A, 86(1): 1-12.
  • Liu, X. S., Zhang, X. H., Huang, A. H., Sajda, P., Ji, B., and Guo, X. E. (2008) Dynamic Simulation of Three Dimensional Architectural and Mechanical Alterations in Human Trabecular Bone during Menopause, Bone, 43(2):292-301.
  • Li, C. Q., Magland, J. F., Rajapakse, C. S., Guo, X. E., Zhang, X. H., Vasilic, B., and Wehrli, F. W. (2008) Implications of Resolution and Noise for In Vivo Micro-MRI of Trabecular Bone, Medical Physics, 35(12):5584-5594.
  • Shi, Y, Yadav, V. K., Suda, N., Liu, X. S., Guo, X. E., Myers, M. G. Jr., and Karsenty, G. (2008) Dissociation of the Neuronal Regulation of Bone Mass and Energy Metabolism by Leptin In Vivo, Proceedings of National Academies of Science, 105(51): 20529-20533.
  • Liu, X. S., Bevil, G., Keaveny, T. M., Sajda, P., and Guo, X. E. (2009) Micromechanical Analyses of Vertebral Trabecular Bone Based on Individual Trabeculae Segmentation of Plates and Rod, Journal of Biomechanics, 40(2): 249-256.
  • Lu, X. L., Mow, V. C., and Guo, X. E. (2009) Proteoglycans and Mechanical Behaviors of Condylar Cartilage, Journal of Dental Research, 88(3): 244-248.
  • Liu, X. S., Zhang, X. H., and Guo, X. E. (2009) Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone, Bone, 45(2): 158-163 (Cover picture).
  • Yadav, V. K., Oury, F., Suda, N., Liu, Z., W. Gao, X. B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., Tecott, L. H., Mann, J. J., Hen, H., Horvath, T. L., and Karsenty, G. (2009) A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure, Cell, 138: 976–989.
  • Rajapakse, C. S., Magland, J., Zhang, X. H., Liu, X. S., Wehrli, S. L., Guo, X. E., and Wehrli, F.W. (2009) Implications of Noise and Resolution on Mechanical Properties of Trabecular Bone Estimated by Image-based Finite-Element Analysis, Journal of Orthopaedic Research, 27(10): 1263-1271.
  • Butler, D.L., Goldstein, S. A., Guldberg, R. E., Guo, X. E., Kamm, R., Laurencin, C. T., McIntire, L. V., Mow, V. C., Nerem, R. M., Sah, R. L., Soslowsky, L. J., Spilker, R. L., and Tranquillo, R. T. (2009) The impact of biomechanics in tissue engineering and regenerative medicine, Tissue Engineering, B Review 15(4): 477-484.
  • Chan, M. E., Lu. X. L., Huo, B., Baik, A. D., Chiang, V., Guldberg, R. E., Lu, H. H., and Guo, X. E. (2009) A Trabecular Bone Explant Model of Osteocyte-Osteoblast Co-Culture for Bone Mechanobiology, Cellular and Molecular Bioengineering, 2(3): 405-415.
  • Cohen, A., Liu, X. S., Stein, E. M., McMahon, D. J., Rogers, H. F., LeMaster, J., Recker, R. R., Lappe, J. M., Guo, X. E., and Shane, E. (2009) Bone Microachitecture and Stiffness in Premenopausal Women with Idiopathic Osteoporosis, The Journal of Clinical Endocrinology & Metabolism, 94(11): 4351-4360.
  • Zaidi, M., Turner, C.H., Canalis, E., Pacifici, R., Sun, L., Iqbal, J., Guo, X. E., Silverman, S., Epstein, S., and Rosen, C.J. (2009) Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep. 7(4):118-126.
  • Huo, B. Lu, X. L., and Guo, X. E. (2010) Intracellular Calcium Wave Propagation in Linear and Looped Bone Cell Networks, Proceedings of the Royal Society A Mathematics, Physics, and Engineering Sciences, 368(1912): 617-633.
  • Yadav, V. K., Balaji, S., Suresh, P.S., Liu, X. S., Lu, X. L., Li, Z., Guo, X. E., Mann, J. J., Balapure, A. K., Medhamurthy, R., Vidal, M., Karsenty, G., Ducy, P. (2010) Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis, Nature Medicine, 16(3):308-312.
  • Shi, X., Liu, X. S., Wang, X., Guo, X. E., and Niebur, G. L. (2010) Effects of Trabecular Type and Orientation on Microdamage Susceptibility in Trabecular Bone, Bone, 46(5): 1260-1266. (Cover Picture)
  • Huo, B. Lu, X. L., Costa, K. D., Xu, Q. and Guo, X. E. (2010) An ATP-Dependent Mechanism Mediates Intercellular Calcium Signaling in Bone Cell Network under Single Cell Nanoindentation, Cell Calcium, 47(3): 234-241.
  • Cohen, A., Dempster, D. W., Müller, R., Guo, X. E., Nickolas, T. L., Liu, X. S., Zhang, X. H., Wirth, A. J., van Lenthe, G. H., Kohler, T., McMahon, D. J., Zhou, H., Rubin, M. R., Bilezikian, J. P., Lappe, J. M., Recker, R.R. and Shane E. (2010) Assessment of Trabecular and Cortical Architecture and Mechanical Competence of Bone by High-Resolution Peripheral Computed Tomography: Comparison with Transiliac Bone Biopsy, Osteoporosis Intl., 21(2): 263-273.
  • Lu, X. L., Wan, L. Q., Guo, X. E., and Mow, V. C. (2010) A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis, J Biomechanics, 43(4):673-679.
  • Grayson, W. L., Fröhlich, M., Yeager, K., Bhumiratana, S., Chan, M. E., Cannizzaro, C., Wan, L. Q., Liu, X. S., Guo, X. E., and Vunjak-Novakovic, G. (2010) Engineering Anatomically-Shaped Human Bone Grafts: The Role of Medium Perfusion, Proceedings of National Academy of Science, 107(8): 3299-3304.
  • Shi Y., Oury, F., Yadav, V. K., Wess, J., Liu X. S., Guo, X. E., Murshed, M., and Karsenty, G. (2010) Signaling through the M(3) Muscarinic Receptor Favors Bone Mass Accrual by Decreasing Sympathetic Activity, Cell Metabolism, 11(3):231-238.
  • Wan, L. Q., Guo, X. E., and Mow, V. C. (2010) A Triphasic Orthotropic Laminate Model for Cartilage Curling Behavior: Fixed Charge Density versus Mechanical Properties Inhomogeneity, ASME J Biomech. Engr., 132(2):02450.
  • Liu, X. S., Zhang, X. H., Sekhon, K. K., Admas, M. F., McMahon, D. J., Bilezikian, J. P., Shane, E., and Guo, X. E. (2010) High-Resolution Peripheral Quantitative Tomography Can Assess Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone and Mineral Research,25(4):746–756.
  • Liu, X. S., Cohen, A. Shane, E., Stein, E., Rogers, H., Kokolus, S. L., Yin, P. T., McMahon, D. J., Lappe, J. M., Recker, R. R., and Guo, X. E. (2010) Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses of High-Resolution Peripheral Quantitative Computed Tomography Images Detects Abnormal Microarchitecture of Plate and Rod Microarchitecture in Premenopausal Women with Idiopathic Osteoporosis, Journal of Bone and Mineral Research, 25(7): 1496-1505.
  • Kulak, C. A., Borba, V. C., Jorgetti, V., Dos Reis, L. M., Liu, X. S., Kimmel, D. B., Kulak J. Jr., Rabelo, L. M., Zhou, H., Guo, X. E., Bilezikian, J. P., Boguszewski, C. L., Dempster, D. W. (2010) Skeletal Microstructure Abnormalities in Postmenopausal Women with Chronic Obstructive Pulmonary Disease, Journal of Bone and Mineral Research, 25(9): 1931-1940.
  • Liu, X. S., Zhang, X. H., Rajapakse, C. S., Wald, M. J., Magland, J., Sekhon, K. K., Adams, M. F., Sajda, P., Wehrli, F. W., and Guo, X. E. (2010) Accuracy of High-Resolution In Vivo Micro Magnetic Resonance Imaging for Measurements of Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone and Mineral Research, 25(9): 2039-2050.
  • Liu, X. S., Cohen, A., Shane, E., Yin, P. T., Stein, E. M., Rogers, H., Kokolus, S. L., McMahon, D. J., Lappe, J. M., Recker, R. R., Lang, T., and Guo, X. E. (2010) Bone Density, Geometry, Microstructure, and Stiffness: Relationships between Peripheral and Central Skeletal Sites Assessed by DXA, HR-pQCT, and cQCT in Premenopausal Women, Journal of Bone and Mineral Research, 25(10): 2229-2238.
  •  Jiang, J., Tang, A., Ateshian, G. A., Guo, X. E., Hung, C. T., and Lu, H. H. (2010) Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair, Annals of Biomedical Engineering, 38(6): 2183-2196.
  • Peng, S., Liu, X. S., Wang, T., Li, Z., Zhou, G., Luk, K. D., Guo, X. E., and Lu, W. W. (2010) In Vivo Anabolic Effect of Strontium on Trabecular Bone Was Associated with Increased Osteoblastogenesis of Bone Marrow Stromal Cells, J. Orthop. Res., 28(9): 1208-1214.
  • Rajapakse, C. S., Magland, J. F., Wald, M. J., Liu, X. S., Zhang, X. H., Guo, X. E., and Wehrli, F. W. (2010) Computational Biomechanics of the Distal Tibia from High-Resolution MR and Micro-CT Images, Bone, 47(3): 556-563.
  • Shi, X., Liu, X. S., Wang, X., Guo, X. E., and Niebur, G. L. (2010) Type and Orientation of Yielded Trabeculae during Overloading of Trabecular Bone along Orthogonal Directions, Journal of Biomechanics, 43(13): 2460-2466.
  • Wan, L. Q., Kang, S. M., Eng, G., Grayson, W. L., Lu, X. L., Huo, B., Gimble, J., Guo, X. E., Mow, V. C. and Vunjak-Novakovic, G. (2010) Geometric Control of Human Stem Cell Morphology and Differentiation, Integrative Biology, 2(7-8): 346-353.
  • Fang, G., Ji, B., Liu, X. S., and Guo, X. E. (2010) Quantification of Trabecular Bone Microdamage Using the Virtual Internal Bond Model and the Individual Trabeculae Segmentation Technique, Computational Methods in Biomechanics and Biomedical Engineering, 13(5): 605-615.
  • Baik, A. D., Lu, X. L., Qiu, J., Huo, B., Hillman, E. M.C., Dong, C., and Guo, X. E. (2010) Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow, Biophysical Journal, 99(9): 2812-2820.
  • Oury, F., Yadav, V. K., Wang, Y., Zhou, B., Liu, X. S., Guo, X. E., Tecott, L. H., Schutz, G., Means, A. R., and Karsenty, G. (2010) CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons, Genes and Development, 24(20): 2330-2342.
  • Stein, E. M., Liu, X. S., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Yin, P. T., Cosman, F., Nieves, J., Guo, X. E., and Shane, E. (2010) Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures, Journal of Bone and Mineral Research, 5(12):2296-2305.
  • Fields, A. J., Lee, G. L., Liu, X. S., Jekir, M. G., Guo, X. E., and Keaveny, T. M. (2011) Influence of Vertical Trabeculae on the Compressive Strength of the Human Vertebra, Journal of Bone and Mineral Research, 26(2):263-269.
  • Peng, S., Liu, X. S., Zhou, G., Li, Z., Luk, K. D.-K., Guo, X. E., and Lu, W. W. (2011) Osteoprotegerin Deficiency Attenuates Strontium-Mediated Inhibition of Osteoclastogenesis and Bone Resorption, Journal of Bone and Mineral Research, 26(6):1272-1282.
  • Wan, L. Q., Jiang, J., Miller, E. D., Guo, X. E., Mow, V. C., and Lu, H. H. (2011) Matrix Deposition Modulates the Viscoelastic Shear Properties of Hydrogel-Based Cartilage Grafts, Tissue Engineering Series A, 17(7-8):1111-1122.
  • Grayson, W. L., Marolt, D., Bhumiratana, S., Fröhlich, M., Guo, X. E., and Vunjak-Novakovic, G. (2011) Optimizing the Medium Perfusion Rate in Bone Tissue Engineering Bioreactors, Biotechnology and Bioengineering, 108(5):1159-1170.
  • Liu, X.S., Walker M.D., McMahon, D.J., Udesky, J., Liu, G., Bilezikian, J.P., and Guo, X. E. (2011) Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women, Journal of Bone and Mineral Research, 26(8):1783-1792.
  • Liu, X. S., McMahon D. J., Shane, E., and Guo, X. E. (2011) Individual Trabeculae Segmentation (ITS)-Based Morphological Analysis of Micro-Scale Images of Human Tibial Trabecular Bone at Limited Spatial Resolution, Journal of Bone and Mineral Research, 26(9):2184-2193.
  • Walker M. D., Liu, X. S., Stein, E. M., Zhou, B., Bezati, E., McMahon, D. J., Udesky, J., Liu, G., Shane, E., Guo, X. E., and Bilezikian, J. P. (2011) Bone Microarchitecture and Stiffness in Postmenopausal Chinese-American and White Women, Journal of Bone and Mineral Research, 26(7):1392-1398.
  • Kajimura, D., Hinoi, E., Ferron, M., Kode, A., Riley, K. J., Zhou, B., Guo, X. E. and Karsenty, G. (2011) Genetic Determination of the Cellular Basis of the Sympathetic Regulation of Bone Mass Accrual, Journal of Experimental Medicine, 208(4):841-851.
  • Stein, E. M., Liu, X. S., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Zhou, B., Cosman, F., Nieves, J., Guo, X. E., and Shane, E. (2011) Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures, The Journal of Clinical Endocrinology & Metabolism, 96(7):2041-2048.
  • Inose, H., Zhou, B., Yadav, V., Guo, X. E., Karsenty, G. and Ducy, P. (2011) Efficacy of serotonin inhibition in mouse models of bone loss, Journal of Bone and Mineral Research, 26(9):2002-11.
  • Hu, M., Li, P., Lü, D., Sun, S., Lomg, M., Guo, X. E., and Huo, B. (2011) Calcium response in osteoblastic pattern without gap junction under flow shear stress, Journal of Medical Biomechanics, 26(5):402-407.
  • Liu, X. S., Stein, E. M., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Zhou, B., Cosman, F., Nieves, J., Shane, E. and Guo, X. E. Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses of High-Resolution Peripheral Quantitative Computed Tomography Images Discriminate Fracture Status in Post-menopausal Women Independent of BMD, Journal of Bone and Mineral Research, in press, 2011.
  • Lu, X. L., Huo B., Chiang, V. C., Baik, A. D., and Guo, X. E. Osteocytic Network Is More Responsive in Calcium Signaling than Osteoblastic Network under Fluid Flow, Journal of Bone and Mineral Research, in press, 2011.
  • Peng S., Liu, X. S., Huang, S., Li, Z., Pan, H., Zhen, W., Luk, K. D., Guo, X. E., Lu, W. W. The Cross-talk between Osteoclasts and Osteoblasts in Response to Strontium Treatment: Involvement of Osteoprotegerin, Bone, in press, 2011.
  • Correia, C., Grayson, W. L., Park, M., Hutton, D., Zhou, B., Guo, X. E., Niklason, L., Sousa, R. A., Reis, R. L., Vunjak-Novakovic, G. In Vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis, PLoS ONE, in press, 2011.
  • Qiu, J., Baik, A. D., Lu, X. L., Zhuang, Z., Hillman, E. M.-C., and Guo, X. E. Theoretical Basis of Quasi-3D Intracellular Strain Measurements, Cellular and Molecular Bioengineering, in press, 2011.

 

Image based microstructural and finite element analyses of skeletons; in vitro mechanobiology of osteocytes, osteoblasts, and osteoclasts; and 3D cell mechanics and mechanotransduction.


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