Nandan Nerurkar

Assistant Professor of Biomedical Engineering 

Research Areas:

mechanobiology of embryonic development and organ formation; birth defects of the central nervous and gastrointestinal systems; morphogenesis.

Email: nln2113@columbia.edu

Morphogenesis and Developmental Biomechanics Lab

EDUCATION

2005-2010: Ph.D., University of Pennsylvania
 
Mechanical Engineering & Applied Mechanics, School of Engineering & Applied Sciences 
 
2003-2005: M.S., Washington University in St. Louis
 
Biomedical Engineering, School of Engineering & Applied Sciences 
 
1999-2003: B.S., University of Maryland at College Park
 
Biological Engineering, A. James Clark School of Engineering 
 
 
PROFESSIONAL EXPERIENCE

2018 – Present: Assistant Professor, Department Biomedical Engineering, Columbia University
 
2011 – 2017: Postdoctoral Fellow, Department of Genetics, Harvard Medical School 
 
 
PUBLICATIONS
 
1. Nerurkar NL, Mahadevan L, Tabin CJ. Molecular control of macroscopic forces drives formation of the vertebrate hindgut (in revision).
 
2. Shah RS, Nerurkar NL, Galloway JL. Zebrafish as a model of adult tendon injury, repair and regeneration (in preparation).
 
3. Nerurkar NL, Mahadevan L, Tabin CJ. Linking signaling to the control of physical forces during morphogenesis: BMP activity and modulation of gut looping. Proceedings of the National Academy of Science, 114(9), 2017.
 
4. Heo SJ, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL. Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. eLife, 5:e18207, 2016.
 
5. Shah RS+ , Nerurkar NL+#, Wang C, Galloway JL#. Tensile properties of craniofacial tendons in the mature and aged zebrafish. Journal of Orthopaedic Research, 33(6), 2015. + authors contributed equally, #cocorresponding authors.
 
6. Shyer AE, Tallinen T, Nerurkar NL, Wei Z, Gil E, Kaplan DL, Tabin CJ, Mahadevan L. Villification: How the gut gets its villi. Science, 342(6155), 2013.
 
7. Han WJ, Nerurkar NL, Jacobs NT, Smith LJ, Mauck RL, Elliott DM. Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading. Annals of Biomedical Eng, 40(7), 2012. 
 
8. Smith LJ, Chiaro JA, Nerurkar NL, Cortes DH, Horava S, Hebela N, Mauck RL, Dodge GR, Elliott DM. Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long term agarose culture. European Cells & Materials, 20(22), 2011.
 
9. Heo SC, Nerurkar NL, Baker BM, Mauck RL. Microstructure dictates stretch-induced cell and nucleus reorganization on aligned nanofibrous scaffolds. Annals of Biomedical Engineering, 39(11), 2011. Cover article.
 
10. Driscoll TP, Nerurkar NL, Jacobs NT, Elliott DM, Mauck RL. Shear mechanics of electrospun scaffold for annulus fibrosus tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials 4(8), 2011.
 
11. Smith LJ, Nerurkar NL, Harfe BD, Elliott DM. Pathogenesis and treatment of intervertebral disc degeneration: lessons from development. Disease Models and Mechanisms, 4(1), 2011.
 
12. Nerurkar NL, Mauck RL, Elliott DM. Modeling inter-lamellar interactions in angle-ply biologic laminates for annulus fibrosus tissue engineering. Biomechanics and Modeling in Mechanobiology, 10(6), 2011.
 
13. Nerurkar NL, Mauck RL, Elliott DM. Selective removal of extracellular matrix components reveals homologous structure-function relationships between engineered and native fibrocartilage. Biomaterials, 32(2), 2011.
 
14. Nathan AS, Baker BM, Nerurkar NL, Mauck RL. Nuclear deformations on nanofibrous scaffolds. Acta Biomaterialia, 7(1), 2011.
 
15. Nerurkar NL, Sen S, Baker BM, Elliott DM, Mauck RL. Dynamic culture enhances stem cell ingress and extracellular matrix deposition on electrospun nanofibrous scaffolds. Acta Biomaterialia 7(2), 2011.
 
16. Nerurkar NL, Elliott DM, Mauck RL. Mechanical design criteria for intervertebral disc tissue engineering. Journal of Biomechanics, 43(6), 2010.
 
17. Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine, 35(8), 2010. Invited for Special Issue.
 
18. Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials, 8(12), 2009. Cover article; Highlighted in News & Views.
 
19. Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. Engineering on the straightand narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Engineering B: Reviews, 15(2), 2009.
 
20. Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. Fabrication and modeling of multi-polymer nanofibrous scaffolds. Journal of Biomechanical Engineering, 131 (10), 2009. Cover article.
 
21. Nerurkar NL, Mauck RL, Elliott DM. ISSLS prize winner: Integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine, 33 (25), 2008.
 
22. Ramasubramanian A, Nerurkar NL, Achtien KH, Filas BA, Voronov DA, Taber LA. On modeling morphogenesis of the looping heart following mechanical perturbation. Journal of Biomechanical Engineering, 130 (6), 2008.
 
23. Nerurkar NL, Elliott DM, Mauck RL. Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. Journal of Orthopaedic Research, 25(8), 2007. Cover article; most referenced JOR paper in 2008.
 
24. Nerurkar NL, Ramasubramanian A, Taber LA. Morphogenetic adaptation of the looping embryonic heart to altered mechanical loads. Developmental Dynamics, 235(7), 2006.
 
25. Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP. Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Phys Heart Circ Phys, 289(3), 2005. 
 
26. Anderson GP, Nerurkar NL. Improved fluoroimmunoassays using the dye Alexa Fluor 647 with the RAPTOR, a fiber optic biosensor. Journal of Immunological Methods, 271 (1-2), 2002. 


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