Education

• 1998: Ph.D., Bioengineering, University of Pennsylvania
  
• 1997: M.S.E., Bioengineering, University of Pennsylvania
  
• 1992: B.S.E., Bioengineering, University of Pennsylvania

Honors and Awards

• 2009-: Member, Editorial Board, Tissue Engineering
• 2008: Society for Biomaterials Young Investigator Award
• 2008: Faculty Diversity Research Fellowship, Columbia University
• 2007: Member, Editorial Advisory Board, Cellular and Molecular Bioengineering
• 2005: International Award for Young Investigator in Orthopedic Biomechanics and Sports Medicine (Y’ROBOTS Award)
• 2005: Wallace H. Coulter Foundation Early Faculty Career Award in Translational Research
• 2001: Co-Managing Editor, Special Issue of Frontiers in Bioscience, “Biomimetics and Tissue Engineering of Skeletal Tissues"
• 1996–98: National Pre-doctoral Research Service Training Award

Research Interests

In the Biomaterials and Interface Tissue Engineering Laboratory, we are interested in the following research areas:

• Interface tissue engineering and mechanisms of soft tissue to bone integration
  • Structure-function relationship at soft tissue-to-bone interfaces
  • Mechanisms of tissue-to-tissue integration: Role of cellular interactions
  • Multi-phasic scaffold design for the formation of complex tissue systems
     
• Mechanism of cell-biomaterial interactions
• Design of composite biomaterials and scaffolds for functional tissue engineering
• Dental and Craniofacial Tissue Engineering

Grant Support

• National Institutes of Health
• Wallace H. Coulter Foundation
• National Football League (NFL) Charities
• Musculoskeletal Transplant Foundation
• Whitaker Foundation
• American Association of Endodontists

Publications - Critical Reviews and Book Chapters

• Moffat KL, Wang IE, Rodeo SA and Lu HH; “Orthopaedic interface tissue engineering for the biological fixation of soft tissue grafts”, Clinics in Sports Medicine, 28(1):15-76, 2009.
• Lu HH and Wang IE, “Multi-scale Co-Culture Models for Orthopaedic Interface Tissue Engineering”, in Biomedical Nanostructures, Gonsalves KE et al. eds., John Wiley & Sons, Inc., 2007.  
• Mikos AG, Herring SW, Ochareon P, Elisseeff J, Lu HH, Kandel R, Schoen FJ, Toner M, Mooney D, Atala A, Van Dyke ME, Kaplan D, Vunjak-Novakovic G, “Engineering Complex Tissues”, Tissue Engineering, 12(12):3307-3339, 2006.
• Lu HH and Jiang JJ, “Interface Tissue Engineering and the Formulation of Multiple-Tissue Systems”, Advances in Biochemical Engineering and Biotechnology, 102:91-111, 2006.  Special Volume: Tissue Engineering, Lee K and Kaplan DL eds., Springer Verlag, New York.

Publications - Select Orignial Research Papers

• Moffat KL, Spalazzi JP, Doty SB, Levine WN and Lu HH; “Novel nanofiber based scaffold for rotator cuff repair and augmentation”, Tissue Engineering, 15(1):115-126, 2009.
• Lu HH, Vo JM, Lin J, Shin S, Cozin M, Tsay R and Landesberg R; “Controlled delivery of growth factors derived from platelet-rich plasma for bone formation”, Journal of Biomedical Materials Research A, 86A(4):1128-1136, 2008.
• Spalazzi JP, Vyner MC, Jacobs MT, Moffat KL, Rich CG and Lu HH; “Mechano-active scaffold induces tendon remodeling and expression of fibrocartilage markers”, Clinical Orthopaedics and Related Research, 466(8):1938-1948, 2008.
• Moffat KL, Sun WA, Pena PE, Chahine NO, Doty SB, Ateshian GA, Hung CT, and Lu HH; “Characterization of the structure-function relationship at the ligament-to-bone interface”, Proceedings of the National Academic of Sciences, 105(23): 7947-7952, 2008.
• Spalazzi JP, Dagher E, Doty SB, Guo XE, Rodeo SA and Lu HH; “In vivo evaluation of multi-phased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration”, Journal of Biomedical Materials Research A, 86A(1): 1-12, 2008.
• Jiang J, Leong NL, Mung J, Hidaka C and Lu HH; “Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP”, Osteoarthritis and Cartilage, 16(1):70-82, 2008.
• Wang IE, Shan J, Choi R, Oh S, Kepler CK, Chen FH and Lu HH; “Role of Osteoblast-Fibroblast Interactions in the Formation of the Ligament-to-Bone Interface”, Journal of Orthopaedic Research, 25(12):1609-1620, 2007.
• Wang IE, Mitroo S, Chen FH, Lu HH* and Doty SB; “Age-dependent changes in matrix composition and organization at the ligament-to-bone insertion”, 24(8):1745-1755, 2006. 
• Spalazzi JP, Gallina J, Fung-Kee-Fung SD, Konofagou EE and Lu HH; “Elastographic Imaging of Strain Distributions within the Anterior Cruciate Ligament and at the Ligament-to-Bone Insertion”, Journal of Orthopedic Research, 24(10):2001-2010, 2006.
• Spalazzi JP, Doty SB, Moffat KL, Levine WN and Lu HH; “Development of Controlled Matrix Heterogeneity on a Triphasic Scaffold for Orthopedic Interface Tissue Engineering”, Tissue Engineering, 12(12):3497-3508, 2006.
• Jiang J, Nicoll SB and Lu HH; “Co-culture of osteoblasts and chondrocytes modulates cellular differentiation in vitro”, Biochemical and Biophysical Research Communications, 338:762-770, 2005.
• Tsay RC, Vo J, Burke A, Eisig SB, Lu HH and Landesberg R; “Differential growth factor retention by platelet-rich plasma composites”, Journal of Oral and Maxillofacial Surgery, 63:521-528, 2005.
• Lu HH, Tang A, Oh S, Spalazzi JP and Dionisio K; “Compositional effects on the formation of a calcium phosphate layer and the response osteoblast-like cells on polymer-bioactive glass composites”, Biomaterials, 26(32):6323-6334, 2005.
• Lu HH, Cooper JA, Manuel S, Freeman JW, Attawia M.A., Ko FK and Laurencin CT; “Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies”, Biomaterials, 26(23):4805-4816, 2005.     
• Lu HH, Jiang J, Tang A, Hung CT, and Guo XE; “Development of controlled heterogeneity on a polymer-ceramic hydrogel scaffold for osteochondral repair,” Bioceramics, 17:609-613, 2004.   
• Spalazzi JP, Dionisio KL, Jiang J, and Lu HH; “Matrix and substrate-dependent effects on osteoblast and chondrocyte interactions during co-culture”, EMBS Magazine, Special Issue in Tissue Engineering, 21(5):104-111, 2003. 
• Lu HH, Scott K, El-Amin SF, and Laurencin CT; “Three-dimensional, bioactive, biodegradable polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization by human osteoblast-like cells in vitro,” Journal of Biomedical Materials Research, 64A:465-474, 2003 2003. 
   

Teaching

• BMEN E3830: Biomedical Engineering Laboratories
  
• BMEN E4501: Tissue Engineering I: Biomaterials and Scaffold Design

Interface tissue engineering and the formation of integrated complex tissue systems, stratified scaffold design for multi-tissue regeneration and multi-scale models to evaluate heterotypic cellular interactions, composite biomaterials for orthopaedic and dental applications