Research Interests

• Cardiovascular cell mechanics
• Techniques and instrumentation for studying cell biology
• Disease and regeneration mechanisms

Publications 

• Feng Y, Yang JH, Huang H, Kennedy SP, Turi TG, Thompson JF, Libby P, Lee RT. The Transcriptional Profile of Mechanically-Induced Genes in Human Vascular Smooth Muscle Cells. Circ Res 1999;85:1118-23.

• Yamamoto K, Dang QN, Maeda Y, Huang H, Kelly RA, Lee RT. Regulation of Cardiomyocyte Mechanotransduction by the Cardiac Cycle. Circulation 2001;103:1459-1464.

• Huang H, Virmani R, Younis H, Burke AP, Kamm RD, Lee RT. The Impact of Calcification Upon the Biomechanical Stability of Atherosclerotic Plaques. Circulation 2001;103:1051-1056.

• Huang H, Kamm RD, So PT, Lee RT. Receptor-Based Differences in Human Aortic Smooth Muscle Cell Membrane Stiffness. Hypertension 2001;38:1158-61.

• Huang H, Dong CY, Kwon H-S, Sutin JD, Kamm RD, So PTC. Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation. Biophys J 2002;82:2211-2223.

• Williamson SD, Lam Y, Younis HF, Huang H, Patel S, Kaazempur-Mofrad MR, Kamm RD. On the sensitivity of wall stresses in diseased arteries to variable material properties. J Biomech Eng 2003;125:147-155.

• Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME. Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci U S A 2003;100:7616-21.

• Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, Kaazempur-Mofrad MR. A Three-dimensional Viscoelastic Model for Cell Deformation with Experimental Verification. Biophys J 2003;85:3336-3349.

• Yoshioka J, Schulze PC, Cupesi M, Sylvan JD, MacGillivray C, Gannon J, Huang H, Lee RT. Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity. Circulation 2004;109:2581-6.

• Huang H, Sylvan J, Jonas M, Barresi R, So PTC, Campbell K, Lee RT. Cell Stiffness and Receptors: Evidence for Cytoskeletal Subnetworks. Am J Physiol Cell Physiol 2005; 288:C72-80.

• Yoshioka J, Prince RN, Huang H, Perkins SB, Cruz FU, MacGillivray C, Lauffenburger DA, Lee RT. Cardiomyocyte Hypertrophy and Degradation of Connexin43 through Spatially Restricted Autocrine/Paracrine HB-EGF. Proc Nat Acad Sci 2005 102(30):10622-7.

• Huang H, Cruz F, Bazzoni G. Junctional Adhesion Molecule-A Regulates Cell Migration and Resistance to Shear Stress. J. Cell Physiol. 2006;209(1):122-30.

• Jonas M, Huang H, Kamm RD, So PT. Fast Fluorescence Laser Tracking Microrheometry I: Instrument Development. Biophys J. 2008;94(4):1459-69.

• Jonas M, Huang H, Kamm RD, So PT. Fast Fluorescence Laser Tracking Microrheometry II: Quantitative Studies of Cytoskeletal Mechanotransduction. Biophys J. 2008 Jul;95(2):895-909.

General responses of cells to physical stimuli, mechanotransduction, cell mechanical properties and adhesion, with focus on cardiovasculature. Development of instrumentation and new techniques for probing cells.