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Gordana Vunjak-Novakovic

Faculty Photo
Gordana Vunjak-Novakovic
Professor of Biomedical Engineering
351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904
New York, NY 10027

Phone: +1 212-305-2304
Fax: +1 212-854-8725
Email:
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Education

  • 1980 Ph.D, Chemical Engineering, University of Belgrade, Serbia 
  • 1986-1987 Fulbright Fellow, Massachusetts Institute of Technology, Cambridge MA 


academic POSITIONS

  • 2005-present   Professor, Department of Biomedical Engineering, Columbia University, New York NY
  • 2005-present   Director, Laboratory for Stem Cells and Tissue Engineering
  • 2007-present   Professor of Biomedical Engineering in Surgery, College of Physicians and Surgeons, Columbia University, New York NY
  • 2007-present   Professor of Biomedical Engineering & Dental and Craniofacial Bioengineering (in Dentistry), College of Dental Medicine, Columbia University, New York NY
  • 2002 - present Adjunct Professor, Department of Biomedical Engineering, Tufts University, Medford MA
  • 2005–present Visiting Scientist, Div. of Health Sciences and Technology, M.I.T., Cambridge MA
  • 1993-  Professor, Department of Chemical Engineering, University of Belgrade, Serbia
  • 1999 – 2005    Principal Research Scientist, Div. of Health Sciences and Technology, M.I.T., Cambridge MA 
  • 1993-1998 Research Scientist, Whitaker College, Massachuestts Insitute of Technology, Cambridge MA
  • 1987-1992 Associate Professor, Department of Chemical Engineering, University of Belgrade, Serbia
 

Awards/Honors (selected)

  • 1997 Medal of recognition, Centennial of the Serbian Chemical Society  
  • 2000 - present  American Institute for Medical and Biological Engineering, Elected Fellow 
  • 2000: Outstanding performance certificate, NASA, Ames Research Center
  • 2003-2007   Space Life Sciences Council
  • 2003-2005 Four NASA awards for bioengineering patents 
  • 2003 Outstanding Performance Medal, World Congress of In Vitro Biology
  • 2004-present Faculty of 1000 Medicine (http://www.f1000medicine.com), Regenerative Medicine Section 
  • 2005  The Association of Orthopedic Research, Switzerland; team award “for the best science in orthopaedics” (with L. Meinel, L. Ziechner, R. Fajardo and D. Kaplan)
  • 2005 Boston Museum of Science: “Tissue engineering and the challenges of imitating nature,” evening with the research group, live televised event, March 18, 2005
  • 2005: Biography in the book Extraordinary Women Engineers by Kendall Andersen (in press, February 2006); photograph on the book cover      
  • 2006 Editor,Tissue Engineering journal, special issue: Tissue engineering - the next generation, December 2006
  • 2007 Keystone Symposium on tissue engineering and Developmental Biology (D4), Chair and organizer (the symposium ranked #6 among all Keystone symposia in the last year)
  • 2007-2012 Editor, new series of Biomedical Engineering books, John Wiley 
  • 2007 NIH Director's Lecture 

Professional Activities (selected)

  • 1987–92 Serbian Academy of Sciences and Arts,  Biomass Committee 
  • 1996-97 Space study of cartilage tissue engineering aboard Mir (with NASA Johnson Space Center and L. E. Freed as the PI)
  • 1996 Scientific oversight of the development and testing of the cell culture system for the International Space Station 
  • 1996 - present  NHLBI, NIBIB, NIDCR, NCI, NASA, NIH DIrector's grants - regular member of special emphasis panels and review groups   
  • 2000 Scientific Advisory Board, Tissue Regeneration Inc., Medford MA
  • 2001 Scientific advisor and founder, GreenFuel, Cambridge, MA 
  • 2001Harvard Dental School, Faculty Search Committee
  • 2001 Scientific Committee, United Engineering Foundation, Microgravity Transport Processes in Fluid, Thermal, Materials and Biological Sciences, Banff, Canada 
  • 2001- 2004: Scientific Advisory Board, co.don, Tetlow, Germany
  • 2002 Society for In Vitro Biology, Scientific Advisory Board
  • 2002 Workshop on Tissue Engineering of Cartilage and Bone, Novartis Foundation, April 9-11, 2002, London UK
  • 2003 - present Board of Directors, Greenfuel, Cambridge MA
  • 2003: Workshop on Skeletal Tissue Engineering, American Academy of Orthopedic Surgeons and the National Institutes of Health, Santa Fe, NM, January 16-19
  • 2003-2004 Tufts University Dental School, External Advisory Board
  • 2004 - present Study section on Biomaterials and Biointerfaces (BMBI), permanent member 
  • 2004 Editorial Board, Woodhead Publishing, Cambridge, England 
  • 2004 Society for In Vitro Biology, Board of Directors  
  • 2004 Scientific Co-chair, World Congress of In Vitro Biology, San Francisco, CA, May 22-26, 2004
  • 2004 Chair, Cellular Toxicology Section, Society for In Vitro Biology
  • 2004 Expert group for the assessment of bioengineering needs in Vietnam, National Science Foundation 
  • 2004 US–China multi-site Workshop on Biomedical Engineering, Beijing and Shanghai, China, July 7-18, 2004
  • 2005 Editorial Board, Tissue Engineering
  • 2005 Editorial Board, Fluid Dynamics and Materials Processing
  • 2005 Editorial Board, Chemical Industry and Chemical Engineering Quarterly
  • 2005 Chair, World Congress of In Vitro biology, Baltimore, MD
  • 2005 Editorial Board, Chemical Industry & Chemical Engineering 
  • 2005 Workshop on the future directions of NIBIB. Atlanta GA, June 2005
  • 2005 Panel of Advisors, Directed tissue self-assembly,  NSF (Frontiers of Integrative Biological Research)  
  • 2005 Convener and Chair (with David Kaplan) of Tissue Engineering 2020, workshop for the National Institutes of Health

Professional Organizations

  • American Association for the Advancement of Science
  • American Institute for Medical and Biological Engineering, Fellow
  • Association of Fulbright Scholars
  • American Chemical Society
  • American Institute of Chemical Engineers
  • Biomaterials Research Society
  • Biomedical Engineering Society
  • Orthopaedic Research Society
  • Society for in vitro Biology (officer)
  • Tissue Engineering Society International

Books

  • Vunjak-Novakovic G. and I. Freshney: Culture of cells for tissue engineering. J. Wiley 2006 
  •  Mao JJ, Vunjak-Novakovic G, Mikos A and Atala A (Editors) Translational Approaches in Tissue Engineering Artech House (in press 2007)
  

Publications (seleted from >200)

  • Freed, L.E., G. Vunjak-Novakovic, P.A. Drinker and R. Langer, A Novel Bioreactor Based on Suspended Particles of Agarose-Immobilized Species, Journal of the American Society for Artificial Internal Organs 34, 732-738, 1988.
  • Bugarski B., G. King, G. Jovanovic, A. Daugulis, M.F.A. Goosen, and G. Vunjak- Novakovic, Design and Operation of an Air-Lift Reactor for Production of Monoclonal Antibodies by Immobilized Hybridoma Cells, Periodicum Biologorum 92 (1) 121-123, 1990.
  • Vunjak-Novakovic G., G. Jovanovic, Lj. Kundakovic and B. Obradovic, Flow Regimes and Liquid Mixing in a Draft Tube Gas-Liquid-Solid Fluidized Bed, Chemical Engineering Science, 47 (13-14), 3451-3458, 1992.
  • Freed, L.E., G. Vunjak-Novakovic and R. Langer, Cultivation of Cell-Polymer Cartilage Implants in Bioreactors, Journal of Cell Biochemistry 51, 257-264, 1993.
  • Freed, L.E., G. Vunjak-Novakovic, P.A. Drinker and R. Langer, A Bioreactor Based on Suspended Particles of Immobilized Enzyme, Annals of Biomedical Engineering 21, 57-65, 1993.
  • Freed, L.E., G. Vunjak-Novakovic, H. Bernstein, C.L. Cooney and R. Langer, The Kinetics of Immobilized Heparinase in Human Blood, Annals of Biomedical Engineering 21, 67-76, 1993.
  • Sajc, L.M., Z.R. Jovanovic, G. Vunjak-Novakovic, G. Jovanovic, R.D. Pesic and D.V. Vukovic, Liquid Dispersion in a Magnetically Stabilized Fluidized Bed (MSFB), Transactions of the Institute of Chemical Engineers 72A, 236-240, 1994.
  • Bugarski B., Q. Li, M.F.A. Goosen, D. Poncelet, R. Neufeld G. Vunjak-Novakovic, Electrostatic Droplet Generation: Mechanism of Polymer Droplet Formation, Journal of the American Institute of Chemical Engineers 40 (6) 913-1092, 1994.
  • Obradovic B., A. Dudukovic and G. Vunjak-Novakovic, Local and Overall Mixing Characteristics of the Gas-Liquid-Solid Air-Lift Reactor, Industrial and Engineering Chemistry Research 33, 698-702, 1994.
  • Freed, L.E., G. Vunjak-Novakovic, R. Biron, D. Eagles, D. Lesnoy, S. Barlow and R. Langer, Biodegradable Polymer Scaffolds for Tissue Engineering, Bio/Technology 12, 689-693, 1994
  • Freed, L.E., J.C. Marquis, G. Vunjak-Novakovic, J. Emmanual, and R. Langer, Composition of Cell-Polymer Cartilage Implants, Biotechnology and Bioengineering 43, 605-614, 1994.
  • Freed, L.E., G. Vunjak-Novakovic, J.C. Marquis, and R. Langer, Kinetics of Chondrocyte Growth in Cell-Polymer Implants, Biotechnology and Bioengineering 43, 597-604, 1994
  • Sajc L., B. Obradovic, D.V. Vukovic, B. Bugarski and G. Vunjak-Novakovic, Hydrodynamics and Mass Transfer in a Four Phase External Loop Air Lift Bioreactor, Biotechnology Progress 11, 420-428, 1995.
  • Langer, R., J.P. Vacanti, C. Vacanti, A. Atala, L.E. Freed and G. Vunjak-Novakovic, Tissue Engineering: Biomedical Applications, Tissue Engineering 1 (2) 151-161, 1995.
  • Freed L.E. and G. Vunjak-Novakovic, Cultivation of Cell-Polymer Constructs in Simulated Microgravity, Biotechnology and Bioenginneering 46, 306-313, 1995.
  • Kundakovic Lj. and G. Vunjak-Novakovic, Mechanics of Particle Motion in Three-Phase Flow, Chemical Engineering Science 50 (20) 3285-3295, 1995.
  • Kundakovic Lj. and G. Vunjak-Novakovic, A Fluid Dynamic Model of the Draft Tube Gas-Liquid-Solid Fluidized Bed, Chemical Engineering Science 50 (23) 3763-3775, 1995.
  • Sajc, L., G. Jovanovic Z. Jovanovic, B. Bugarski, J. Vukovic and G. Vunjak-Novakovic, Liquid Dispersion in a Magnetically Stabilized Fluidized Bed (MSFB), Mixed-Flow Hydrodynamics, Advances in Engineering Fluid Mechanics, pp. 713-740, 1995.
  • Vunjak-Novakovic, G., L.E. Freed, R.J. Biron and R. Langer, Effects of Mixing on Tissue Engineered Cartilage, Journal of the American Institute of Chemical Engineers 42 (3) 850-860, 1996.
  • Freed, L.E., Langer, R., Martin, I., Pellis, N., Vunjak-Novakovic, G. Tissue engineering of cartilage in space, Proceedings of the National Academy of Sciences USA, Vol. 94: 13885-13890, 1997; commentary in same issue on pp. 13380-13382.
  • Freed, L.E. and G. Vunjak-Novakovic, Tissue Culture Bioreactors: Chondrogenesis as a Model System, in Principles of Tissue Engineering, R.P. Lanza, R. Langer and W.L. Chick, eds., Landes and Springer Verlag, Ch. 11, pp. 151-165, 1997.
  • Vunjak-Novakovic G., Obradovic B., Bursac P., Martin I., Langer R., Freed L.E., Dynamic Seeding of Polymer Scaffolds for Cartilage Tissue Engineering, Biotechnology Progress 14: 193-202, 1998.
  • Martin, I, Padera, R.F., Vunjak-Novakovic, G., Freed, L.E. In Vitro Differentiation of Chick Embryo Bone Marrow Stromal Cells into Cartilaginous and Bone-like Tissues, Journal of Orthopedic Research 16: 181-189, 1998.
  • Freed, L.E., Hollander, A.P., Martin, I., Barry, J.R., Martin, I., Vunjak-Novakovic, G. Chondrogenesis in a Cell-Polymer-Bioreactor System, Experimental Cell Research 240: 58-65, 1998.
  • Riesle J., Hollander A.P., Langer R., Freed L.E. and Vunjak-Novakovic G. Collagen in Tissue Engineered Cartilage: Types, Structure and Crosslinks. Journal of Cellular Biochemistry 71: 313-327 1998.
  • Freed, L.E., Vunjak-Novakovic, G., Culture of Organized Cell Communities, Advanced Drug Delivery Reviews 33 (1, 2) 15-30 1998.
  • Obradovic B., Carrier R.L., Vunjak-Novakovic G.V., Freed L.E. Oxygen Is Essential for Bioreactor Cultivation of Tissue Engineered Cartilage. Biotechnology and Bioengineering 63: 197-205, 1999.
  • Vunjak-Novakovic G., Martin I., Obradovic B., Treppo S., Grodzinsky A.J., Langer R., Freed L. Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue Engineered Cartilage, Journal of Orthopedic Research 17: 130-138, 1999.
  • Freed L.E., Martin I., Vunjak-Novakovic G. Frontiers in Tissue Engineering: In Vitro Modulation of Chondrogenesis, Clinical Orthopedics and Related Research 367S: S46-S58, 1999.
  • Carrier R., Papadaki M., Rupnick M., Schoen F.J., Bursac N., Langer R., Freed L.E, Vunjak-Novakovic G. Cardiac Tissue Engineering: Cell Seeding, Cultivation Parameters and Tissue Construct Characterization, Biotechnology and Bioengineering 64: 580-589, 1999.
  • Bursac N., Papadaki M., Cohen R.J., Schoen F.J., Eisenberg S.R., Carrier R., Vunjak-Novakovic G., Freed L.E. Cardiac Muscle Tissue Engineering: Towards an In Vitro Model for Electrophysiological Studies. American Journal of Physiology 277 (Heart Circ. Physiol. 46): H433-H444, 1999.
  • Martin I., Obradovic B., Freed L.E., Vunjak-Novakovic G. A Method for Quantitative Analysis of Glycosaminoglycan Distribution in Cultured Natural and Engineered Cartilage. Annals of Biomedical Engineering 27 (5) 1-7, 1999.
  • Martin, I., Vunjak-Novakovic, G., Yang, J., Langer, R., Freed, L.E. Mammalian Chondrocytes Expanded in the Presence of Fibroblast Growth Factor-2 Maintain the Ability to Differentiate and Regenerate Three-Dimensional Cartilaginous Tissue. Experimental Cell Research 253: 681-688, 1999.
  • Martin I., Obradovic B., Treppo S., Grodzinsky A., Langer R., Freed L.E., Vunjak-Novakovic G. Modulation of the mechanical properties of tissue engineered cartilage. Biorheology 37: 141-147, 2000.
  • Sajc L., Grubisic D. and Vunjak-Novakovic G. Bioreactors for Plant Tissue Engineering: An Outlook for further Research. Biochemical Engineering Journal (Japan) 4: 89-99, 2000.
  • Sajc L., Vunjak-Novakovic G. Concurrent liquid-liquid extractive bioconversion in a four-phase external-loop airlift bioreactor, Journal of the American Institute of Chemical Engineers 46: 1368-1375, 2000.
  • Obradovic B., Meldon J.H., Freed L.E., Vunjak-Novakovic G. Glycosaminoglycan deposition in tissue engineered cartilage: experiments and mathematical model. Journal of the American Institute of Chemical Engineers 46: 1860-1871, 2000.
  • Freed L.E., Vunjak-Novakovic G. Tissue engineering bioreactors. In: Principles of Tissue Engineering, 2nd edition, Academic Press, R. Lanza, R. Langer and J. Vacanti (ed.), Ch. 13, 143-156, 2000. 
  • Schaefer, D., Martin, I., Shastri, P., Padera, R.F., Langer, R., Freed, L.E. and Vunjak-Novakovic, G. In vitro generation of osteochondral composites. Biomaterials 21 (24): 2599-2606, 2000.
  • Freed, L.E. and G. Vunjak-Novakovic, “Cell-Polymer-Bioreactor Systems”. In: Methods of Tissue Engineering (A. Atala and R.P. Lanza, eds., Academic Press) Ch. 6, pp. 99-114, 2001.
  • Papadaki, M. , Bursac, N. , Langer, R., Merok, J., Vunjak-Novakovic, G., Freed, L.E. Tissue Engineering of Functional Cardiac Muscle: Molecular, Structural and Electrophysiological Evaluations American Journal of Physiology, Heart Circ Physiol 280: H168-H178, 2001 (cover article)
  • Gooch, K.J., Kwon, J.H., Blunk, T., Langer, R., Freed, L.E., Vunjak-Novakovic, G. Effects of mixing intensity on tissue engineered cartilage. Biotechnology and Bioengineering 72: 402-407, 2001. 
  • Gooch, K.J., Blunk, T., Courter, D.L., Sieminski, A.L., Bursac, P.M., Vunjak-Novakovic, G., Freed, L.E. IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development, Biochemical and Biophysical Research Communications 286: 909-915, 2001.
  • Martin I., Shastri V.P., Padera R.F., Yang J., Mackay A.J., Langer R., Vunjak-Novakovic G., Freed L.E. Selective differentiation of mammalian mesenchymal progenitor cells cultured on three-dimensional polymer foams. Journal of Biomedical Materials Research 55: 229-235, 2001.
  • Martin, I., Suetterlin, R., Baschong, W., Heberer, M., Vunjak-Novakovic, G., and Freed, L.E. Enhanced Cartilage Tissue Engineering by Sequential Exposure of Chondrocytes to FGF-2 During 2D Expansion and BMP-2 During 3D Cultivation. J Cellular Biochemistry 83: 121-128, 2001.
  • Freed, L.E., Rupnick, M.A., Schaefer, D., Vunjak-Novakovic, G. Engineering Functional Cartilage and Cardiac Tissue: In Vitro Culture Parameters. In: Functional Tissue Engineering: the Role of Biomechanics (F. Guilak, D. Butler, D. Mooney, S. Goldstein, eds), Springer Verlag, New York, pp. 360-376 (2003)
  • Gooch, K.J., Blunk, T., Courter, D.L., Sieminski, A.L., Vunjak-Novakovic, G., Freed, L.E. Bone Morphogenic Proteins-2, -12, and –13 Modulate In Vitro Development of Engineered Cartilage, Tissue Engineering 8(1): 591-601, 2002.
  • Blunk T, Sieminski AL, Gooch KJ, Courter DL, Hollander A, Nahir AM, Langer R, Vunjak-Novakovic G, Freed LE. Differential Effects of Growth Factors on Tissue-Engineered Cartilage. Tissue Engineering 8: 73-84, 2002.
  • Obradovic B., Martin, I., Padera, R.F., Treppo, S. , Freed, L.E., and Vunjak-Novakovic, G. Integration of engineered cartilage. Journal of Orthopedic Research 19 (6): 1089-1097, 2001.
  • Vunjak-Novakovic G , Obradovic B., Martin I., Freed L.E. Bioreactor studies of native and tissue engineered cartilage. Biorheology 39:259-268, 2002.
  • Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE and Vunjak-Novakovic G. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Engineering 8 (2) 175-188, 2002.
  • Vunjak-Novakovic, G., de Luis J., Searby N., Freed L.E. Microgravity Studies of Cells and Tissues. Annals of the New York Academy of Sciences, Vol. 974: Microgravity Transport Processes in Fluid, Thermal, Materials and Biological Sciences, pp. 504-517, 2002.
  • Freed, L.E. and G. Vunjak-Novakovic, Spaceflight Bioreactor Studies of Cerlls and Tissues. In: Advances in Space Biology and Medicine, vol. 8: Cell Biology and Biotechnology in Space (A. Cogoli, ed.), Elsevier Science pp. 177-195, 2002.
  • Altman, G., Horan, R.L., Martin, I., Farhadi J., Stark, P.R.H., Volloch, V., Richmond, J.C., Vunjak-Novakovic, G., Kaplan, D.L. Cell Differentiation by Mechanical Stress. FASEB J. 16(2): 270-272, 2002.
  • Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE and Vunjak-Novakovic G. Effects of oxygen on engineered cardiac muscle. Biotechnology and Bioengineering 78 (6): 616-624, 2002. 
  • Schaefer D., Martin I., Jundt G., Seidel J., Heberer M., Grodzinsky A., Bergin I., Vunjak-Novakovic G., Freed L.E. Tissue engineered composites for the repair of large osteochondral defects. Arthritis and Rheumatism 46(9): 2524-2534 (2002)
  • Pei M., Seidel J., Vunjak-Novakovic G. and Freed L.E. Growth factors for sequential cellular de- and re-differentiation in tissue engineering. Biochemical and Biophysical Research Communications 294(1):149-154, 2002.
  • Pei M, Solchaga LA, Seidel J, Zeng L, Vunjak-Novakovic G, Caplan AI, Freed LE. Bioreactors mediate the effectiveness of tissue engineering scaffolds. FASEB J. 16: 1691-1694, 2002.
  • Madry H, R Padera, J Seidel, R Langer, LE Freed, SB Trippel and G Vunjak-Novakovic. Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Human Gene Therapy 13(13): 1621-1630, 2002.
  • Altman GH, Stark P, Lu HH, Horan RL, Calabro T, Martin I, Ryder D, Richmond JC, Vunjak-Novakovic G and DL Kaplan. Advanced bioreactor with multi-dimensional strain and biomimetic capability for tissue engineering. Journal of Biomechanical Engineering 124: 742-749, 2002.
  • Radisic M., Euloth M., Yang L., Langer R., Freed L.E., Vunjak-Novakovic G. High density seeding of myocyte cells for tissue engineering. Biotechnology and Bioengineering 82: 403-414, 2003.
  • Bursac N, Papadaki M, White JA, Eisenberg S, Vunjak-Novakovic G and Freed LE. Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. Tissue Engineering 9: 1243-1253, 2003.
  • Vunjak-Novakovic G. Fundamentals of tissue engineering: scaffolds and bioreactors. In: Tissue Engineering of Cartilage and Bone. A. Caplan (Ed.), John Wiley pp. 34-51 (2003); Book review in Annals of Biomedical Engineering 32(2) 314-315, 2004.
  • Vunjak-Novakovic G. and Radisic M. Cell seeding of polymer scaffolds. Methods in Molecular Biology, pp. 131-146, 2004.
  • Meinel L, Kareourgiou V, Fajardo R, Snyder B, Shinde-Patil V, Zichner L, Kaplan D, Langer R and Vunjak-Novakovic G, Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Annals of Biomedical Engineering 32: 112-122, 2004. Paper highlighted at the ISI web site as one of the most frequently cited.
  • Radisic M., Yang L., Boublik J., Cohen R.J., Langer R., Freed L.E., Vunjak-Novakovic G. Medium perfusion enables engineering of compact and contractile cardiac tissue. American Journal of Physiology 286: H507–H516, 2004.
  • Mauney, J., J. Blumberg, M. Pirun, V. Volloch, G. Vunjak-Novakovic, D.L. Kaplan. Osteogenic differentiation of human bone marrow stromal cells on 3D partially demineralized bone scaffolds in vitro. Tissue Engineering 10(1-2): 81-92, 2004.
  • Vunjak-Novakovic G., Obradovic B., Madry H., Altman G., Kaplan D. Bioreactors for orthopaedic tissue engineering. In Orthopaedic tissue engineering: Basic science and practice (ed. A.I. Caplan and V. Goldberg), Marcel Dekker Inc. New York , pp. 123-147 (2004)
  • Mauney JR, Sjostrom S, Blumberg J, Horan R, O’Leary JP, Vunjak-Novakovic G, Volloch V, and Kaplan DL. Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcified Tissue International 74(5):458-68 (2004)
  • Vunjak-Novakovic G. Functional tissue engineering of cartilage: scaffolds and bioreactors. Tissue Engineering in Musculoskeletal Clinical Practice (ed. L.J. Sandell and A.J. Grodzinsky) Transactions of the American Academy of Orthopaedic Surgeons pp. 321-330 (2004)
  • Vunjak-Novakovic G, Altman G and Kaplan D. Tissue engineering of ligaments. Annual Review of Biomedical Engineering 6:131-156 (2004)
  • Seidel JO, Pei M, Gral ML, Langer R, Freed LE and Vunjak-Novakovic G. Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation. Biorheology 41(3-4):445-458 (2004)
  • Meinel L, Karageorgiou V, Hoffmann S, Fajardo R, Snyder B, Li C, Zichner L, Langer R, Vunjak-Novakovic G and Kaplan DL. Engineering bone-like tissue using human mesenchymal stem cells and silk scaffolds. Journal of Biomedical Materials Research 71A: 25-34 (2004)
  • Meinel L, R Fajardo, S Hofmann, R Langer, J Chen, B Snyder, G Vunjak-Novakovic, and DL Kaplan. Silk implants for healing critical size cranial defects. Bone 37(5): 688-698, 2005. 
  • Meinel L, Hoffmann S, Karageorgiou V, Zichner L, Langer R, Kaplan DL and Vunjak-Novakovic G. Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds. Biotechnology and Bioengineering 88(3): 379-391 (2004)
  • Radisic M., Park H., Shing H., Consi T., Schoen F., Langer R., Freed L.E., Vunjak-Novakovic G. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds Proceedings of the National Academy of Sciences 101(52):18129-18134 (2004) (cover article)
  • Moreau JE, Chen J, Bramono DS, Volloch V, Chernoff H, Vunjak-Novakovic G, Richmond JC, Kaplan DL, Altman GH. Growth factor induced fibroblast differentiation from human bone marrow stromal cells in vitro. Journal of Orthopaedic Research 23(1):164-74 (2005)
  • Vunjak-Novakovic G. and S. Goldstein, Biomechanical principles of Cartilage and Bone Tissue Engineering. In: Basic Orthopaedic Biomechanics and Mechanobiology, 3rd edition (V.C. Mow and R. Huiskes Ed.), Lippincot-Williams and Wilkens, Chapter 8, pp. 343-408 (2005)
  • Radisic M, Deen W, Langer R and Vunjak-Novakovic G. Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium supplemented with synthetic oxygen carriers American Journal of Physiology 288: H1278 - H1289 (2005)
  • Kim HJ, Kim U-J, Vunjak-Novakovic G, Min B-H and Kaplan D. Bone regeneration by bone marrow stem cells on macroporous silk scaffolds. Biomaterials 26: 4442-4452 (2005)
  • Tognana E, Chen F, Padera R, Leddy H, Christensen S, Guilak F, Vunjak-Novakovic G and Freed LE. Adjacent tissues (cartilage, bone) affect the functional integration of engineered cartilage in vitro, Osteoarthritis and Cartilage 13: 129-138 (2005)
  • Tognana E, Chen F, Padera R, Vunjak-Novakovic G and Freed LE. Chondrogenesis and integrative repair of engineered cartilage in vitro and in vivo ,Osteoarthritis and Cartilage 13: 129-138 (2005)
  • Kaplan DL, Moon R and Vunjak-Novakovic G. It takes a village to grow a tissue. Nature Biotechnology 23 (10): 1237-1239, 2005
  • Radisic M, Obradovic B. and Vunjak-Novakovic G. Functional tissue engineering of cartilage and myocardium: bioreactor aspects. In: Scaffolding in Tissue Engineering. (P.X. Ma and J. Elisseeff ed.) Marcel Dekker, Chapter 33, pp. 491-520 (2005)
  • Boublik I, Park H, Radisic M, Tognana E, Chen F, Pei M, Vunjak-Novakovic G and Freed LE. Hybrid cardiac grafts made of heart cells and an elastomeric knitted fabric: mechanical characterization and in vivo implantation. Tissue Engineering 11 (7/8) 1122-1132 (2005)  
  • Radisic M, Malda J, Eric Epping E,, Geng W, Langer R and Vunjak-Novakovic G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnology and Bioengineering 93(2):332-343, 2005
  • Vunjak-Novakovic G, Meinel L, Altman G, Freed LE and Kaplan D. Bioreactor cultivation of osteochondral tissues. Orthodontics and Craniofacial Research 8: 209-218 (2005) 
  • Hofman S, Wong P, Foo CT, Rossetti F, Textor M, Vunjak-Novakoic G, Kaplan DL, Merkle HP, Meinel L. Silk fibroin as an organic polymer for controlled drug delivery. J Control Release111(1-2):219-27, 2006
  • Gerecht-Nir S, Radisic M, Park H, Boublik J, Cannizzaro C, Langer R, Vunjak-Novakovic G. Biophysical regulation of cardiogenesis. International Journal of Developmental Biology 50(2-3):233-43, 2006.  
  • Karp JM, Yeo Y, Geng W, Cannizarro C, Yan K, Kohane DS, Vunjak-Novakovic G, Langer R and Radisic M. A Photolithographic Method to Create Cellular Micropatterns Biomaterials 27(28): 4993-5002, 2006. 
  • KarageorgiouV, Tomkins M, Fajardo R, Meinel L, Snyder B, Wade K, Chen J, Vunjak-Novakovic G and Kaplan DL. Porous Silk Fibroin 3D Scaffolds for Delivery of Bone Morphogenetic Protein-2 in Vitro and in Vivo. Journal of Biomedical Materials Research 78A(2): 324-334, 2006. 
  • Murthy SK, Sethu, P, Vunjak-Novakovic G, Toner M. and Radisic M. Size-Based Microfluidic Fractionation of Neonatal Rat Cardiac Cells. Biomedical Microdevices 8(3):231-237, 2006. 
  •  Tandon N., Voldman J. and Vunjak-Novakovic G.Characterization of Electrical Stimulation Electrodes for Cardiac Tissue Engineering. IEEE 1: 845-848, 2006. 
  • Marsano A., Vunjak-Novakovic G. and Martin I.Towards Tissue Engineering of Meniscus Substitutes: Selection of Cell Source and Culture Environment. IEEE 1: 3656-3658, 2006, 
  •  Meinel L, S Hofmann, OB Betz,, R Fajardo, V Karageorgiou, HP Merkle, R Langer, CH Evans, G Vunjak-Novakovic and DL Kaplan. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: a comparison of adenovirus mediated gene transfer and protein delivery of BMP-2 Biomaterials 27(28):4993-5002, 2006. 
  • Meinel L, Betz O, Fajardo R, Hofmann S, Nazarian A, Hilbe M, McCool J, Langer R, Vunjak-Novakovic G, Merkle HP, Rechenberg B, Kaplan DL, Kirker-Head C Silk-based biomaterials for the healing of critical-size long bone defects. Bone 39(4):922-931, 2006. 
  • Hofmann S, Knecht S, Stussi E, Langer R, Kaplan D, Vunjak-Novakovic G, Merkle HP,Meinel L. Cartilage-like Tissue Engineering Using Silk Scaffolds and Mesenchymal Stem Cells Tissue Engineering 12(10): 2729-2738, 2006
  •  Marolt D, Augst A, Vepari C, Farley M, Fajardo R, Patel N, Gray ML, Freed LE, Kaplan DL and Vunjak-Novakovic G. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials 27(36): 6138-6149, 2006. 
  • Wang Y, Kim H-J, Vunjak-Novakovic G and Kaplan DL. Stem cell based tissue engineering with silk biomaterials. Review article. Biomaterials, special issue on Stem Cells 27(36): 6064-6082, 2006
  • Vunjak-Novakovic G. Transplants made to order, The Scientist 20(9): 35-41, 2006. 
  • Radisic M, Park H, Chen F, Wang Y, Dennis R, Langer R, Freed LE and Vunjak-Novakovic G. Biomimetic approach to cardiac tissue engineering: Oxygen carriers and channeled scaffolds Tissue Engineering 12 (8): 2077-2091, 2006 (Cover article) Editors choice, Drug Discovery April 2007. 
  • Vunjak-Novakovic G. and Kaplan DL. Foreword to the special NIH edition of Tissue engineering Journal. Tissue Engineering 12(12) 3259-3260, 2006. 
  • Vunjak-Novakovic G. and Kaplan DL. Tissue engineering – the next generation. Editorial. Tissue Engineering 12(12) 3261-3264, 2006. 
  • Ingber D, Mow VC, Butler D, Niklason L, Huard J, Mao JJ, Yannas I, Kaplan DL and Vunjak-Novakovic G. Tissue Engineering and Developmental Biology: Going Biomimetic. Tissue Engineering 12(12) 3265-3284, 2006. 
  • Freed LE, Guilak F, Guo XE 3, Gray ML, Tranquillo R, Holmes J, Radisic M, Sefton MV, Kaplan DL and Vunjak-Novakovic G. Advanced Tools: Scaffolds, Bioreactors, Signaling. Tissue Engineering 12(12) 3285-3306, 2006. 
  • Mikos A, Herring S, Elisseeff JE, Lu H, Kandel R, Schoen FJ, Toner M, Mooney DL, Atala A, Kaplan DL and Vunjak-Novakovic G. Engineering Complex Tissues. Tissue Engineering 12(12) 3307-3340, 2006. 
  • Hunziker E, Spector M, Libera J, Gertzman A, Woo S L-Y, Ratcliffe A, Lysaght M, Coury A, Kaplan DL and Vunjak-Novakovic G. From Research to Applications: Translation. Tissue Engineering 12(12) 3241-3364, 2006. 
  • Uebersax L, Hagenmuller H, Hofmann S, Gruenblatt E, Muller R, Vunjak-Novakovic G, Kaplan DL, Merkle HP, Meinel L. Effect of Scaffold Design on Bone Morphology in Vitro. Tissue Engineering. 12(12) 3417-3430, 2006. 
  • Hoffman S, Hagenmueller H, Koch A, Mueller R, Vunjak-Novakovic G, Kaplan D, Merkle HP and Meinel LW. Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds. Biomaterials 28(6):1152-1562, 2007. 
  • Khademhosseini A, Eng G, Yeh J, Kucharczyk S, Langer R, Vunjak-Novakovic G and Radisic M. Microfluidic patterning for fabrication of contractile cardiac organoids. Biomedical Microdevices 9(2): 149-157, 2007. 
  • Cannizzaro C, Tandon N, Figallo E, Park H, Gerecht S, Radisic M, Elvassore N and Vunjak-Novakovic G. Practical aspects of cardiac tissue engineering with electrical stimulation. Methods in Molecular Medicine, Tissue Engineering (H Hauser and M. Fussenegger), Humana Press, 291-307, 2007.      
  • Park H, Cannizzaro C, Langer R, Vunjak-Novakovic G, Vacanti CA, Farokhzad OC. Micro- and Nanofabrication of functional materials for tissue engineering (Review article) Tissue Engineering 13(8):1867-1877, 2007. 
  •  Iyer R, Radisic M, Cannizzaro C and Vunjak-Novakovic G. Oxygen carriers in cardiac tissue engineering. Artificial Cells Blood Substitutes and Biotechnology 35 (1): 135-148, 2007. 
  • Ferreira L, Gercht-Nir S, Shieh H, Vunjak-Novakovic G and Langer R. Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials 28(17): 2706-2717 (2007) Highlighted in Materials Today: “Hydrogels make stem cells differentiate” 10(5): 10 (May 2007) 
  • Ferreira L, Gerecht-Nir S, Shieh H, Vunjak-Novakovic G and Langer R.Vascular progenitor cells isolated from human embryonic stem cells Circulation Research E published June 14, 2007. 
  • Radisic M, Park H, Gerecht-Nir S, Cannizzaro C, Langer R., Vunjak-Novakovic G. Biomimetic approach to cardiac tissue engineering. Philosophical Transactions of the Royal Society of London – B Biological Sciences 362(1484):1357-1368, 2007. 
  • Figallo E., Cannizzaro C, Gerecht-Nir S, Burdick J, Langer R, Elvassore N and Vunjak-Novakovic G. Microbioreactor for controlled differentiation of human embryonic stem cells. Lab on a Chip7 (6): 710 - 719, 2007. Cover article. 
  • Chang G, Jin HJ, Kaplan DL, Vunjak-Novakovic G and Kandel R. Porous silk scaffolds can be used for tissue engineering annulus fibrosus. European Spine Journal Epub ahead of print, April 20, 2007. 
  • Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R. and Vunjak-Novakovic G. Propagation of undifferentiated human embryonic stem cells in hyaluronic acid hydrogels. PNAS 104(27): 11298-11303, 2007. 
  • Hagenmüller H, Hofmann S, Kohler T, Merkle HP, Kaplan DL, Vunjak-Novakovic G, Müller R and Meinel L. Noninvasive time-lapsed monitoring and quantification of engineered bone-like tissue. Annals of Biomedical Engineering 2007 Jun 2; [Epub ahead of print] 
  • Gerecht S, Bettinger CJ, Zhang Z, Borenstein J, Vunjak-Novakovic G, Langer R. The effect of actin disrupting agents on contact guidance of human embryonic stem cells.. Biomaterials 28(28):4068-4077, 2007. 
  • Chao PhG, Grayson W and  Vunjak-Novakovic G. Engineering cartilage and bone using human mesenchymal stem cells. Journal of Orthopaedic Science 12(4):398-404. 2007. 
  • Lovett M, Cannizzaro C, Daheron L, Messmer B, Vunjak-Novakovic G and Kaplan DL. Silk fibroin microtubes for blood vessel engineering. Biomaterials Epub August 27, 2007. 
  • Khademhosseini A, Karp JM, Gerecht S, Ferreira L, Vunjak-Novakovic G and Langer R. Embryonic stem cells as a Cell Source for Tissue Engineering. Principles of Tissue Engineering 3rd ed.  (Lanza, Langer and Vacanti ed.) 2007. 
  • Radisic M, Park H and Vunjak-Novakovic G. Cardiac tissue engineering. Principles of Tissue Engineering 3rd ed.  (Lanza, Langer and Vacanti ed.) 2007. 
  • Freshney I, Obradovic B Grayson W, Cannizzaro C and Vunjak-Novakovic G. Principles of tissue culture and bioreactor design. Principles of Tissue Engineering 3rd ed.  (Lanza, Langer and Vacanti ed.) 2007.
  • Gerecht S, Cannizzaro C, Figallo E, Elvassore N, and Vunjak-Novakovic G. Bioreactors for the 3D cultivation of human embryonic stem cells. Human Embryonic Stem Cells (ed. J. Masters, B. Palsson, J. Thomson), Human Cell Culture Series, Springer Verlag, Ch. 9, pp. 149-172, 2007.
  • Radisic M, Malda J, Eric Epping E, Geng W, Langer R and Vunjak-Novakovic G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnology and Bioengineering (in press) 1.     
  • Radisic M., Park H., Salazar-Lazaro JE., Wang Y. Langer R., Freed LE., Vunjak-Novakovic G. Sequential cultivation of cardiac cell subpopulations results in robust contractile response of engineered cardiac tissue Journal of Biomedical Materials Research A (in press) 
  • Jakab K, Damon B, Marga F, Neagu A, Besch-Williford CL, Kachurin A, Park H, Mironov V, Markwald R, Vunjak-Novakovic G and Forgacs G. Tissue engineering by self-assembly of cells printed into topologically defined structures. Tissue Engineering (in press) 

   

Popular Press, News and Views (selected)

  • Microgravity News, Profile: Lisa Freed and Gordana Vunjak-Novakovic, Fall 1998.
  • Scientific American “Tissue engineering: Challenges ahead,” April 1999, pp. 86-89
  • PBS Scientific American Frontiers: Never Say Die, with Alan Alda, Jan. 25, 2000.
  • PBS Scientific American Frontiers: Ask the Scientists, November 2000.
  • Popular Science, “Growing Hearts from Scratch” pp. 47–50, April 2000 (cover story)
  • Chemical & Engineering News “Biomaterials Body Shop” pp. 33 – 42, June 26, 2000
  • Chemical Engineering Progress, “Model describes engineered cartilage”, September, 2000
  • JAMA, “Cell Biology Update: A Decade of Simulating Space on Earth”, by Vastag, B. May 2, 2001. (JAMA vol. 285, pp. 2181-2182). 
  • Newsweek, “Cures for the Future”, by Rogers, A. Fall/Winter 2001, p. 73 
  • PBS and Canadian Broadcast Company “Masters of Technology”, Fall 2002.
  • The Varsity "How to Fix a Broken Heart in Ten Easy Steps", April 17, 2003.
  • Drug Discovery & Development. “Labs Have Growing Interest in Cell Culture Automation”. November 2003.
  • Nature 421: 884-886 (2003) “The beat goes on”. C. Zandonella (News Feature article)
  • The Scientist “Cell Culture Automation”, pp. 37-38, March 1, 2004.
  • IEEE Engineering in Medicine and Biology “Around the world - biomedical engineering in Vietnam today”. V V Toi , D. Childress, R. Jaeger, D. Kaplan, M.H. Loe, G. Vunjak-Novakovic and J. G. Webster. 24 (3) 11-17 (2005)
  • Boston Globe “The algae alternative” Evan I. Schwartz, July 12, 2004
  • MIT Spotlight: Photosynthesis turns single-cell algae into tiny power plants. August 13, 2004.
  • Toronto Star “Rebuilding broken hearts” Article by Rachel Ross, September 27, 2004. 
  • Wired: A Patch for Broken Hearts. December 13, 2004.
  • Scientific American: Electrical Signals Key to Culturing Heart Tissue. December 14, 2004.
  • The Boston Globe (cover page): MIT grows beating heart tissue. by Stephen Smith, December 14, 2004
  • BBC: Beating heart tissue grown in lab. December 15, 2004
  • BioWorld Today: In heart tissue engineering, it’s electricity, gap, scaffolds. December 29, 2004. pp. 1, pp. 5
  • IEEE Spectrum magazine “The Body Shops”, Featured article, Carol Ezzell Webb, February 17 2005.
  • New York Times: Bioengineering: Patching broken hearts. By Steven Smith. January 5, 2005
  • MIT Web page spot light: Engineers aim to mend broken hearts. February 14, 2005.
  • Technologies of the month: Ex vivo growth of bioengineered ligaments and other tissues. Lifelike mechanical loads cause cell cultures to grow into lifelike structures. NASA Tech Briefs, March 2005, pp. 62-63
  • Tech Talk: Tissue engineering: a real growth field. March 29, 2005.
  • WGBH & Boston Museum of Science: Science forum. March 29, 2005. 
  • Technology review. Emerging technologies. Patches for the perfect pump: mending broken hearts, by Stu Hutson. Pp. M9, May 2005.
  • Boston Globe. Technology to mimic Mother Nature: Researchers look to tap into a whole world of possibilities. Interview, August 22, 2005