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Helen H. Lu

Faculty Photo
Helen H. Lu
Associate Professor of Biomedical Engineering, Assistant Professor of Dental and Craniofacial Bioengineering
351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904

Phone: +1 212-854-4071
Fax: +1 212-854-8725
Email:
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Education

  • 1998: Ph.D., Bioengineering, University of Pennsylvania

  • 1997: M.S.E., Bioengineering, University of Pennsylvania

  • 1992: B.S.E., Bioengineering, University of Pennsylvania

Professional Experience

  • 2004- : Assistant Professor of Dental and Craniofacial Bioengineering, Columbia University

  • 2001- : Assistant Professor of Biomedical Engineering, Columbia University
    Director, Biomaterials and Interface Tissue Engineering Laboratory
  • 2001: Post-doctoral Fellow, Chemical Engineering, Tufts University

  • 1998: Post-doctoral Fellow, Chemical Engineering, Drexel University

Honors and Awards

  • 2001: Co-Managing Editor, Frontiers in Bioscience special issue, “Biomimetics and Tissue Engineering of Skeletal Tissues”

  • 1999: Society for Biomaterials Travel Award

  • 1996-98: National Pre-doctoral Research Service Training Award

Research Interests

In the Biomaterials and Interface Tissue Engineering Laboratory, we are interested in the following research areas:

  • Interface tissue engineering and mechanisms of soft tissue to bone integration
  • Design of composite biomaterials and scaffolds for functional tissue engineering
  • Mechanism of cell-biomaterial interactions
  • Dental biomedical engineering

Grant Support

  • Whitaker Foundation

  • American Association of Endodontists

Publications

  • Lu HH, Cooper JA, Manuel S, Freeman JW, Attawia MA, Ko FK, and Laurencin CT; “Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies,” Biomaterials, In Press.
  • Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, and Landesberg R; “Differential growth factor retention by platelet-rich plasma composites,” Journal of Oral and Maxillofacial Surgery, In Press.
  • Landesberg R, Burke A, Pinsky D, Katz R, Vo J, Eisig SB, and Lu HH; “Activation of platelet rich plasma using thrombin receptor agonist peptide,” Journal of Oral and Maxillofacial Surgery, In Press.

  • Lu HH and Jiang JJ, "Interface tissue engineering and the formulation of multiple-tissue systems," Advances in Biochemical Engineering/Biotechnology, Special Volume: Tissue Engineering, Lee K. and Kaplan D.L., eds, Springer Verlag, New York, In Press.
  • Cooper JA, Lu HH, Ko FK, and Laurencin CT; “Fiber-based, tissue engineered scaffold for ligament replacement: design considerations and in vitro evaluations,” Biomaterials, 26(13):1523-1532, 2005.
  • Lu HH, Jiang J, Tang A, Hung CT, and Guo XE; “Development of controlled heterogeneity on a polymer-ceramic hydrogel scaffold for osteochondral repair,” Bioceramics, 17:609-613, 2004.

  • Spalazzi JP, Dionisio KL, Jiang J, and Lu HH; “Matrix and substrate-dependent effects on osteoblast and chondrocyte interactions during co-culture”, EMBS Magazine, Special Issue in Tissue Engineering, 21(5):104-111, 2003.
  • Hung CT, Lima EG, Mauck RL, LeRoux MA, Lu HH, Stark RG, Guo XE, and Ateshian GA; “Anatomically shaped osteochondral constructs for articular cartilage repair,” Journal of Biomechanics, 36:1853-1864, 2003.
  • Lu HH, Kofron MD, El-Amin SF, Attawia MA, and Laurencin CT; “In vitro bone formation using muscle-derived cells: A new paradigm for bone tissue engineering,” Biochemical and Biophysical Research Communications, 305:882-889, 2003.
  • Altman GH, Lu HH, Horan RL, Calabro T, Ryder D, Kaplan DL, Stark P, Martin I, Richmond JC, and Vunjak-Novakovic G; “Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering,” Journal of Biomechanical Engineering, 124:742-749, 2003.
  • Lu HH Scott K, El-Amin SF, and Laurencin CT; “Three-dimensional, bioactive, biodegradable polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization by human osteoblast-like cells in vitro,” Journal of Biomedical Materials Research, 64A:465-474, 2003.
  • El-Amin SF, Lu HH, Khan Y, Burems J, Mitchell J, Tuan RS, and Laurencin CT; “Extracellular matrix production by human osteoblasts cultured on biodegradable polymers applicable for tissue engineering.” Biomaterials, 24(7):1213-21, 2003.
  • Altman GH, Horan RL, Lu HH, Moreau J, Martin I, Richmond JC, and Kaplan DL; “Silk-based biomaterials,” Biomaterials, 24(3):401-416, 2002.
  • Altman GH, Lu HH, Horan R, Moreau J, Martin I, Richmond J, and Kaplan DL; “Silk matrix for tissue engineered anterior cruciate ligaments,” Biomaterials, 23(20):4131-4141, 2002.
  • El-Amin SF, Attawia M, Lu HH, Shah AK, Chang R, Hickok N, Tuan RS, and Laurencin CT; “Human osteoblast integrin expression on degradable polymeric materials for tissue engineered bone,” Journal of Orthopaedic Research, 20(1):20-28, 2002.
  • Laurencin CT and Lu HH; Polymer-ceramic composites for bone tissue engineering, in “Bone Engineering”, Davies J.E. ed., Emsquared, Toronto, Canada, 2002.

  • Laurencin CT, Attawia MA, Borden MD, Lu HH, Gorum WJ, and Lieberman J; “Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration,” Biomaterials, 22(11), 1271-1277, 2001.
  • Lu HH, Pollack SR, and Ducheyne P; “45S5 bioactive glass zeta potential variations and the formation kinetics of a glass surface calcium phosphate layer in a fibronectin-containing solution,” Journal of Biomedical Materials and Research, 54:455-462, 2001.
  • Lu HH, Pollack SR, and Ducheyne P; “Temporal zeta potential variations of 45S5 bioactive glass immersed in an electrolyte solution,” Journal of Biomedical Materials and Research, 51:80-87, 2000.

Teaching

  • BMEN E3830: Biomedical Engineering Laboratories

  • BMEN E4502: Tissue Engineering II: Biomaterials and Scaffold Design