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Elizabeth M. C. Hillman

Faculty Photo
Elizabeth M. C. Hillman
Assistant Professor of Biomedical Engineering
351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904

Phone: +1 212-854-2788
Fax: +1 212-854-8725
Email:
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Education

  • 1998: M.Sci. (B.Sc. + M.Sc.), Physics, University College London, London, UK
  • 2002: Ph.D., Medical Physics and Bioengineering, University College London, London, UK

Professional Experience

  • 2002-3: Manager of In Vivo Spectroscopy, Argose Inc., Waltham, MA
  • 2005-6: Instructor, Massachusetts General Hospital (Radiology), Harvard Medical School, Boston, MA
  • 2006- : Assistant Professor, Biomedical Engineering, Columbia University, New York, NY
  • 2006- : Assistant Professor, Radiology, Columbia Presbyterian, New York, NY

Research Experience

  • 1997: High Energy Particle Physics Group, University College London, London, UK (Summer)


  • 2003-5: Post-doctoral Research Fellow, Martinos Center for Biomedical Imaging (Radiology), Massachusetts General Hospital, Boston, MA

Professional affiliations

  • Optical Society of America (OSA)

  • The International Society for Optical Engineering (SPIE)

  • Society for Neuroscience (SFN)

  • International Society for Cerebral Blood Flow and Metabolism (ISCBFM)


Honors and Awards

  • Wellcome Trust Prize Studentship, Ph.D. Fellowship (1998-2002)
  • Outstanding Short Paper Award, Rank Prize Fund Mini-symposium on applications of fast low-level light detection, Grasmere, UK (2000)
  • Poster Award, Gordon Research Conference: Lasers in Medicine and Biology 2000
  • Travel Awards for OSA BIOMED 2000, 2006, Gordon Conference LMB 2000, SPIE Photonics West 2001, Gordon Conference (Brain blood flow and metabolism) 2004, Brain'05 2005.
  • Program Committee Member, SPIE Optics East 2005 & 2006 Optical Methods in Drug Discovery and Development

  • Session Chair (Optics in Neuroscience) and Program Committee Member for National Institute of Health Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside, 2006

  • Session Chair (Imaging brain function and disease), Lasers in Medicine and Biology Gordon Conference 2006)

  • NIH Study Section Reviewer, ZEB1 OSR-A M1 S: “New Ways to Image Neural Activity” 2006

  • NIH Study Section reviewer: ZRG1 BST-M (50) R: "Nanotechnology" 2007

  • NIH Study Section reviewer: BMIT: "Biomedical Imaging Technology" 2007

  • OSA BIOMED 2008 Program Chair: “Diffuse optical imaging and tomography”



Grant Support

  • National Institute of Neurological Disorders and Stroke (NINDS), PI
  • National Heart, Blood and Lung Institute (NHLBI), subcontract Co-PI
  • National Cancer Institute (NCI), imaging core
  • Wallace H. Coulter Foundation (Young Investigator), PI
  • Human Frontier Science Program Grant, PI

Publications

  • Hillman E. M. C. and Moore A. "All-optical anatomical coregistration for small animal molecular imaging using dynamic contrast", Nature Photonics, 1 (9): 526-530 (2007).



  • Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. “Depth-resolved optical imaging of transmural electrical propagation in perfused heart”, Optics Express, 15 (26), 17827-17841, (2007).

  • Hillman E. M. C. “Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man”, J Biomed Opt.  12(5), 051402 (2007). *Also selected to appear in the “Virtual Journal of Biological Physics Research”



  • Hillman E. M. C., Devor A., Bouchard M. B., Dunn A. K., Krauss G. W., Skoch J., Bacskai B. J., Dale A. M., Boas D. A. “Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007).



  • Devor A, Tian P, Nishimura N, Teng IC, Hillman E M C, Narayanan S N, Ulbert I, Boas D A, Kleinfeld D, Dale A M. “Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007).



  • Custo A., Wells W. M., Barnett A. H., Hillman E. M. C., Boas D. A. "Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse Optical Imaging", Appl Opt. 44 (11): 2082-2093 (2006).



  • Zhang Q., Brukilacchio T. J., Li A., Stott J. J., Chaves T., Hillman E. M. C., Wu T., Chorlton M. A., Rafferty E., Moore R. H., Kopans D. B., Boas D. A. "Co-registered Tomographic X-ray and Optical Breast Imaging: Initial Results", J Biomed Opt, 10(2), 024033-1-9 (2005).



  • Corlu A., Choe R., Durduran T., Lee K., Schweiger M., Arridge S. R., Hillman E. M. C., Yodh A. G. "Diffuse optical tomography with spectral constraints and wavelength optimization", Appl Opt, 44(11), 2082-2093 (2005).



  • Li A., Boverman G., Zhang Y., Brooks D., Miller E. L., Kilmer M. E., Zhang Q., Hillman E. M. C., Boas D. A. "An optimal linear inverse solution given multiple priors in diffuse optical tomography", Appl Opt, 44(10), 1948-1956 (2005).



  • Hillman, E. M. C., Boas, D. A., Dale, A. M., Dunn, A. K. "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media", Optics Letters, 29, (14), 1650-1652 (2004).



  • Hillman, E. M. C. "Optical tomography", Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003).



  • Corlu, A., Durduran, T., Choe, R., Schweiger, M., Hillman, E. M. C., Arridge, S. R. Yodh, A. G. "Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography", Optics Letters, 28, 23, 2339-2341 (2003).



  • Hebden, J. C., Gonzalez, F. M., Gibson, A., Hillman, E. M. C., Yusof, R., Everdell, N., Delpy, D. T., Zaccanti, G., and Martelli, F. "Assessment of an in situ temporal calibration method for time-resolved optical tomography", J Biomed Opt 8, 87-92 (2003).



  • Hebden, J. C., Gibson, A., Yusof, R., Everdell, N., Hillman, E. M. C., Delpy, D. T., Arridge, S. R., Austin, T., Meek, J. H., Wyatt, J. S. "Three-dimensional optical tomography of the premature infant brain", Phys. Med. Biol , 47, 23, 4155-4166 (2002).



  • Hebden, J. C., Veenstra, H., Dehghani, H., Hillman, E. M. C., Schweiger, M., Arridge, S. R., and Delpy, D. T. "Three dimensional time-resolved optical tomography of a conical breast phantom", Applied Optics 40 19, 3278-3287 (2001).



  • Hillman, E. M. C., Hebden, J. C., Schweiger, M., Dehghani, H., Schmidt, F. E. W., Delpy, D. T., Arridge, S. R. "Time Resolved Optical Tomography of the Human Forearm", Phys. Med. Biol, 46, 4, 1117-1130 (2001).



  • Hillman, E. M. C., Hebden, J. C., Schmidt, F. E. W., Arridge, S.R., Schweiger, M., Dehghani, H., Delpy, D.T. "Calibration techniques and datatype extraction for time-resolved optical tomography", Rev Sci Instrum, 71, 9, 3415-3427 (2000).



  • Schmidt, F. E. W., Hebden, J. C., Hillman, E. M. C., Fry, M. E., Schweiger, M., Delpy, D. T. "Multiple slice imaging of a tissue-equivalent phantom using time-resolved optical tomography", Applied Optics 39, 19, 3380-3387 (2000).



  • Arridge, S. R., Hebden, J. C., Schweiger, M., Schmidt, F. E. W., Fry, M. E., Hillman, E. M. C., Dehghani, H. "A method for 3D time-resolved optical tomography". J. Imaging. Syst. Technol, 11, 2-11 (2000).



  • Schmidt, F. E. W., Fry, M. E., Hillman, E. M. C., Hebden, J. C., and Delpy, D.T. "A 32-channel time-resolved instrument for medical optical tomography", Rev. Sci. Instrum 71, 1, 256-265 (2000).



  • Hebden, J. C., Schmidt, F. E. W., Fry, M. E., Schweiger, M., Hillman, E. M. C., Delpy, D. T., and Arridge, S. R. "Simultaneous reconstruction of absorption and scattering images using multi-channel measurement of purely temporal data", Optics Letters, 24, 8, 534-536. (1999).



  • Elwell, C. E., Springett, R., Hillman, E. M. C., Delpy, D.T. "Oscillations in Cerebral Haemodynamics – Implications for Functional Activation Studies". Adv. Exp Med & Biol 471, 57-65 (1999).