Elisa E. Konofagou

Professor of Biomedical Engineering and Radiology

351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904
New York, NY 10027

Phone: +1 212-342-0863 +1 212-854-9661
Fax: +1 212-342-1648
Email: ek2191@columbia.edu
 

Research Areas:

Ultrasonics (imaging and therapy), elasticity imaging, signal and image processing, soft tissue mechanics.
Lab Web Site

 

 

Professional Experience

1. 11/93-10/94             Biomedical engineer                                     
Onassis Cardiac Surgery Center and N.C.S.R. Demokritos, Athens, Greece

2. 8/99- 10/99              Postdoctoral fellow
Department of Radiology, University of Texas Medical School, Houston, TX.   

3. 11/99-6/02               Research fellow
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

4. 7/02-9/03                 Instructor
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

5. 10/03-02/09             Assistant Professor
Department of Biomedical Engineering, Columbia University, New York, NY

6. 5/04-02/09               Assistant Professor
Department of Radiology, Columbia University, New York, NY

7. 03/09-present          Associate Professor
Department of Biomedical Engineering, Columbia University, New York, NY

8. 03/09-present          Associate Professor
Department of Radiology, Columbia University, New York, NY

 

9. 01/14-present          Professor
Department of Biomedical Engineering, Columbia University, New York, NY

10. 01/14-present        Professor
Department of Radiology, Columbia University, New York, NY

 

Research Experience

  • 1991: Research Assistant, Institut de Pierre et Marie Curie, University of Paris VI, Paris, France, Summer.
  • 1992: Research Assistant, Department of Physics, Charles University, Prague, Czechia, Summer
  • 1993-94: Research Assistant, National Center for Scientific Research (N.C.S.R.) Demokritos, Athens, Greece
  • 1994-99: Research Assistant, University of Texas Medical School-Houston, Houston, TX
  • 1999-2002: Research Fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
  • 2002-3: Instructor, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

 

Professional Affiliations

  •  Acoustical Society of America
  •  American Association for the Advancement of Science
  •  American Heart Association
  •  American Institute of Ultrasound in Medicine (Member of the Technical Standards Committee of the AIUM conference)
  •  Eta Kappa Nu
  •  Faculty of 1000
  •  Hellenic Bioscientific Society in the USA (HBS-USA)
  •  Houston Society for Engineering in Medicine and Biology
  •   Institute of Electrical and Electronic Engineering (IEEE) Society for Ultrasonics, Ferroelectrics and Frequency Control
  •   Institute of Electrical and Electronic Engineering (IEEE) Engineering in Medicine and Biology (EMBS)
  •   Institute of Electrical and Electronic Engineering (IEEE) Women in Engineering
  •   International Society of Therapeutic Ultrasound (ISTU)
  •   New York Academy of Sciences
  •   Sigma Xi
  •   SPIE optical engineering society
  •   Society of Neuroscience
  •   Society of Women in Engineering
  •   World Technology Network

 

Honors and Awards

1994-1999         University of Texas Medical School-Houston, Graduate fellowship

1997                 Hellenic Professional Society of Texas Scholarship

1999                 Graduate Student Achievement Award, Sigma Xi competition - UH chapter

1999                 RWB Stephens Student prize, World Conference in Ultrasound '99, Copenhagen, Denmark

2000                 Award for the Best Non-Clinical Paper published in the journal of Ultrasound in Medicine and

                         Biology in 1998 from the World Federation of Ultrasound in Medicine and Biology

2002                 Young Investigator Award, Acoustical Society of America

2003                 New Investigator Award (finalist), World Federation for Ultrasound in Medicine and Biology, Montreal, Canada

2004                 American Heart Association Scientist Development Award

2005                 Wallace H. Coulter Early Career Development Award

2006                 New Investigator Award winner, American Institute of Ultrasound in Medicine, Washington, DC

2006                 Press release selection out of 1,000 abstracts, Acoustical Society of America, Providence, RI

2006                 Nominated for the 2006 World Technology Award in ‘Health and Medicine’, 2006 World Technology Summit,
                         San  Francisco, CA, Nov. 2006.

2006                 Nominated for the Presidential Early Career Award in Science and Engineering (PECASE) by the National
                         Institutes  of  Health (NIH).

2007                 NSF CAREER Award recipient and nominated for the Presidential Early Career Award in  Science and Engineering
                         (PECASE) by the National Science Foundation (NSF).

2007                 Nagy Award by the National Institute of Biomedical Imaging and Bioengineeiring (NIBIB) – NIH.

2008                 Columbia University Diversity Initiative Award

2009                 New Investigator Award winner, American Institute of Ultrasound in Medicine, New York, NY  (with PhD student
                         Wei-Ning Lee)   

2009                  International Society of Therapeutic Ultrasound Early Career Award

2011                 Invited Participant, Frontiers of Engineering, National Academy of Engineering, San Francisco, CA

2012                 Elected member, Board of Governors, American Institute of Ultrasound in Medicine (AIUM)

2014                 Fellow, American Institute for Medical and Biological Engineering (AIMBE)

2014                Biomedical Wellness Pioneer Award, SPIE Defense, Security, and Sensing (DSS) Meeting

 

Grant Support

  • National Institutes of Health: NIH R01 EB006042: Early Detection and Mapping of Ischemia using Myocardial Elastography
  • National Institutes of Health: NIH R01 EB009041: Optimization of Ultrasound-Induced Blood-Brain Barrier Opening
  • National Science Foundation: NSF CAREER 0644713 : Therapeutic Ultrasound and the Blood-Brain Barrier
  • National Institutes of Health: NIH R21 EY018505: Ultrasound-induced Drug Delivery using Focused Ultrasound 
  •  National Institutes of Health: NIH R21 EB008521: A Novel System For Simultaneous Generation And Monitoring Of Tumor Ablation
  •  National Institutes of Health: NIH R01 HL098830: Noninvasive qualitative and quantitative assessment of vascular disease in vivo.
  •  National Institutes of Health: NIH 1R01AG038961: Assessment of ultrasound-facilitated neurotherapeutics.
  •  National Institutes of Health: NIH 1R01EB014496: Ultrasound-based tumor targeting and thermal ablation monitoring system.
  •  National Institutes of Health: NIH 1R01 HL 114358: Noninvasive arrhythmia mapping using Electromechanical Wave Imaging.
  •  National Institutes of Health: NIH R21 HL096094 (PI: Konofagou): Noninvasive Conduction Mapping using Electromechanical Wave Imaging.
  •  Seed Grant Radiological Society of North America Harmonic Motion Imaging: A Novel Method for the Assessment of Mechanical
    Properties of Tissues for the Detection of Stiff Nodules
  • Scientist Development Grant
  • American Heart Association a Novel Imaging Technique for the Assessment of Myocardial Contractility
  • Wallace H. Coulter Early Career Development Award: An Elastocardiography Prototype Module for Echocardiography in the detection of heart
    disease
  • Kinetics Foundation Pilot Grant: Ultrasound-induced molecular delivery in Parkinson’s disease.
  • Kavli Foundation Pilot Grant: Ultrasound-induced molecular delivery in the visual cortex and hippocampus.
  • Wallace H. Coulter Foundation Pilot Grant: A noninvasive drug delivery system for focal treatment of brain diseases.
  • Focused Ultrasound Surgery Foundation Seed Grant: FUS-mediated treatment for neurological and neurodegenerative diseases.

Publications

  • Konofagou E.E., Dutta, P., Ophir, J. and Cespedes, I., Reduction of Stress Nonuniformities by Apodization of Compressor Displacement in Elastography, Ultrasound in Medicine and Biology 22(9), 1229-1236, 1996.
  • Konofagou E.E., Ophir, J., Kallel, F. and Varghese, T., Elastographic Dynamic Range Expansion using Variable Applied Strains, Ultrasonic Imaging 19, 145-166, 1997.
  • Konofagou E.E., Varghese, T. and Ophir, T., Variable Compressions with RF and Baseband Processing for Dynamic Range Expansion of Elastograms, Journal of Medical Ultrasonics (Japan) 24(5) 753-760, 1997. [Invited].
  • Alam S.K., Ophir, J. and Konofagou E.E., An Adaptive Stretching Estimator for Elastography, IEEE Transactions of Ultrasonics, Ferroelectrics and Frequency Control 45(2), 461-472, 1998.
  • Konofagou E.E. and Ophir, J., A New Elastographic Method for Estimation and Imaging of Lateral Strains, Corrected Axial Strains and Poison's Ratios in Tissues, Ultrasound in Medicine and Biology 24(8), 1183-1199, 1998.
  • Ophir J., Alam S. K., Garra B., Kallel F., Konofagou E.E., Krouskop T. and Varghese T., Elastography: Ultrasonic estimation and imaging of elastic properties of tissues, Journal of Engineering in Medicine, Proceedings of the Institute of Mechanical Engineers 213(H), 203-233, 1999. [Invited].
  • Konofagou E.E., Varghese T., Ophir J. and Alam S. K., Incoherent and Direct Spectral Strain Estimators in Elastography, Ultrasound in Medicine and Biology 25 (7), 1115-1129, 1999.
  • Kallel F., Price R., Konofagou E.E. and Ophir J., Elastographic Imaging of the Dog Prostate In-Vitro, Ultrasonic Imaging 21(3), 201-215, 1999.
  • Konofagou E.E., Harrigan T. and Ophir J., Shear Strain Estimation and Lesion Mobility Assessment in Elastography, Ultrasonics 38(1-8), 400-404, 2000.
  • Konofagou E.E., Varghese T. and Ophir J., Spectral Estimators in Elastography, Ultrasonics38(1-8), 412-416, 2000.
  • Ophir J., Garra B., Kallel F., Konofagou E.E., Krouskop T., Righetti R. and Varghese T., Elastographic imaging, Ultrasound in Medicine and Biology 26 Suppl. 1, 23-29, 2000.
  • Konofagou E.E. and Ophir J., Precision Estimation and Imaging of the Three-Dimensional Normal and Shear Strain Tensor Principal Components, Physics in Medicine and Biology 45(6), 1553-63, 2000 [Invited].
  • Varghese, T., Konofagou E.E.,Ophir, J. and Alam, S.K., Direct Strain Estimation in Elastography Using Spectral Cross-correlation, Ultrasound in Medicine and Biology 26(9), 1525-37, 2000.
  • Konofagou E.E.,Varghese T. and Ophir J., A Fundamental Limit on the Estimation of Transverse Displacement, Transverse Strain and Poisson’s Ratio in Elastography, Ultrasonic Imaging 22(3), 153-177, 2000.
  • Ophir J., Kallel F., Varghese T., Konofagou E.E., Alam S. K., Garra B., Krouskop T. and Righetti R., Elastography, Optical and Acoustic Imaging of Acoustic Media, C.R. Acad. Sci. Paris, Tome 2, Serie IV, No. 8, 1193-1212, 2001. [Invited].
  • Konofagou E.E., Thierman J. and Hynynen K., A New Focused Ultrasound Method for Dual Diagnostic and Therapeutic Applications – A Simulation Study, Physics in Medicine and Biology 46(11): 2967-2984, 2001.
  • Konofagou E.E., Harrigan T., Ophir J. and Krouskop T., Poroelastography: Estimation and Imaging of the Poroelastic Properties of Tissues, Ultrasound in Medicine and Biology 27(10): 1387-1397, 2001.
  • Varghese T., Konofagou E.E.,Ophir, J., Kallel F., and Righetti, R., Fundamentals of    Elastographic Imaging, Ultrasonic Imaging 23:216-248, 2001.
  • Konofagou E.E., D’hooge J. and Ophir J., Myocardial Elastography – An In Vivo Feasibility Study, Ultrasound in Medicine and Biology 28(4), 475-482, 2002.
  • D’hooge J., Konofagou E.E., Jamal F., Heimdal A., Barrios L., Bijmens B., Thoen J., Van de Werf F., Sutherland G. and Suetens P., Two-dimensional Strain Rate Measurement of the Human Heart In Vivo, IEEE Transactions in Ultrasonics, Ferroelectrics and Frequency Control 49, 281-286, 2002.
  • Konofagou E.E.., Thierman J. Karjalainen T. and Hynynen K., The Temperature Dependence of Ultrasound-Stimulated Acoustic Emission, Ultrasound in Medicine and Biology 28(3), 331-338, 2002.
  • Ophir J., Alam S.K., Garra B., Kallel F., Konofagou E.E., Krouskop T., Merritt C.R.B., Righetti, R., Souchon, R., Srinivasan, S. and Varghese T., Elastography: Imaging the Elastic Properties of soft Tissues with Ultrasound, Journal of the Japan Society of Ultrasonics in Medicine 29: 155-171, 2002 [Invited].
  • Konofagou E.E., Thierman J. and Hynynen K., The Use of USAE Frequency Shift in the Monitoring of Modulus Changes with Temperature, Ultrasonics 41(5): 337-45, 2003.
  • Konofagou E.E. and Hynynen K., Localized Harmonic Motion Imaging: Theory, Simulations and Experiments, Ultrasound in Medicine and Biology 29: 1405-13, 2003.
  • Konofagou E.E. Ottensmeyer M., Dawson S.L. and Hynynen K., Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus, Ultrasonics 42, 951-956, 2004.
  • Konofagou E.E., Quo vadis Elasticity Imaging?, Ultrasonics 42, 331-336, 2004 [Invited].
  • Harrigan T. and Konofagou E.E., Estimation of material elastic moduli in elastography: A local method, and an investigation of Poisson ratio sensitivity, Journal of Biomechanics 37(8), 1215-1221, 2004.
  • Langevin H.M., Konofagou E.E., Badger G. J., ChurchillD. L., FoxJ.R., OphirJ. and Garra B. S., Displacement Imaging During Acupuncture Using Elastographic Techniques, Ultras. Med. Biol. 30(9), 1173-1183, 2004.
  • Konofagou E.E. and Langevin H.M. Using Ultrasound To Understand Acupuncture, IEEE Engineering in Medicine and Biology Magazine 24(2), 41-46, 2005 [Invited].
  • Spalazzi J.P., Gallina J., Fung-kee-Fung S., Konofagou E.E. and Lu H.H., Elastographic Imaging of Strain Distribution in the Anterior Cruciate Ligament and at the Ligament-Bone Insertions, Journal of Orthopedics Research 24(10):2001-10, 2006.
  • Morda L.S., Lim W.-K. and Konofagou E.E.., Left-Ventricular Segmentation Using Autocovariance Techniques, Ultrasonic Imaging 28(3), 159-78, 2006.
  • Maleke, C., Pernot, M. and Konofagou E.E.., A Single-Element Focused Transducer Method for Harmonic Motion Imaging,Ultrasonic Imaging28(3), 144-58, 2006 [Invited].
  • Choi J.J., Pernot M., Small S., and Konofagou E.E.., Non-invasive, Transcranial, and Localized Opening of the Blood-Brain Barrier in Mice using Focused Ultrasound – A Feasibility Study, Ultrasound in Med. Biol. 33: 95-104, 2007.
  • Zervantonakis I. K., Fung-kee-Fung S.D., Lee W.-N. and Konofagou E.E.., A Novel View-Independent Method for Strain Estimation in Myocardial Elastography - Eliminating Angle- and Centroid-Dependence, Phys. Med. Biol. 52, 4063-4080, 2007.
  • Pernot M., Fujikura K., Fung-kee-Fung S. and Konofagou E.E.., ECG-synchronized, ultrafast ultrasound imaging of cardiovascular tissues in intact mice, Ultras. Med. Biol. 33(7):1075-85, 2007.
  • Luo J., Fujikura K., Homma S. and Konofagou E.E..,Myocardial Elastography at both High Temporal and Spatial Resolution for the Detection of Murine Infarcts, Ultras. Med. Biol., Vol. 33, No. 8, pp. 1206–1223, 2007.
  • Langevin H.M., Rizzo D.M., Fox J.R., Stevens-Tuttle D., Konofagou E.E.., Bouffard N.A., Badger G.J., and Krag M.H., Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound, BMC Systems Biology 5;1:25. 2007.
  • Choi J.J., Pernot M., Brown T.R., Small S., and Konofagou E.E..,A Spatio-temporal analysis of molecular delivery through the blood-brain barrier using focused ultrasound, Phys. Med. Biol. 52: 5509-5530, 2007.
  • Lee W-N., Ingrassia C., Fung-kee-Fung S., Costa K.D. Holmes, J.W. and Konofagou E.E.. A Theoretical Framework for Quality Assessment in Myocardial Elastography, IEEE Trans. Ultras. Ferroel. Freq. Control., Vol. 54, No.11, 2233-2245, 2007.
  • Fujikura K., Luo J., Gamarnik V., Pernot M., Fukumoto R., Homma S., Tilson III M.D. and Konofagou E.E.., A Novel Non-Invasive Technique for Pulse-wave Imaging and Characterization of Vascular Mechanical Properties In-Vivo, Ultrasonic Imaging 29, 137-154, 2007.
  • Luo J. and Konofagou E.E.., High Frame-Rate, Full-View Myocardial Elastography With Automated Contour Tracking In Vivo, IEEE Trans. Ultras. Ferroel. Freq. Control., Vol. 55, No. 1, 240-248, 2008.
  • Maleke C. and Konofagou E.E., Harmonic Motion Imaging For Focused Ultrasound (HMIFU): A Fully Integrated Technique For Sonication And Monitoring Of Thermal Ablation In Tissues, Phys. Med. Biol., Vol. 53,   No. 6, 1773-1793, 2008.
  • Katouzian A., Baseri B., Konofagou E.E.., and Carlier S.G., Challenges in Atherosclerotic Plaque Characterization with Intravascular Ultrasound (IVUS): From Data Collection to Classification, IEEE Information Technology in Biomedicine, Vol. 12,  No. 3, 315-327, 2008.
  • Shan B, Pelegri AA, Maleke C, Konofagou E.E. A mechanical model to compute elastic modulus of tissues for harmonic motion imaging. J Biomech. 41(10):2150-2158, 2008.
  • Lee W-N. and Konofagou E.E.., Angle-Independent and Multi-Dimensional Myocardial Elastography: From Theory to Clinical Validation, Ultrasonics 48(6-7):563-7, 2008 [Invited].
  • Wang S., Lee W-N, Provost J, Luo J. and Konofagou E.E.., A Composite High-Frame-Rate System For Clinical Cardiovascular Imaging, IEEE Trans. Ultras. Ferroel. Freq. Control., 55: 2221-2233, 2008.
  • Lee W-N., Qian Z., Tosti C.L., Brown, T.R., Metaxas D.N. and Konofagou E.E.. Preliminary Validation Of Angle-Independent Myocardial Elastography Using MR Tagging In A Clinical Setting, Ultras. Med. Biol. 34(12):1980-97, 2008.
  • Choi J.J., Wang S., Brown T.R., Small S.A., Duff K.E. and Konofagou E.E.., Noninvasive and Transient Blood-Brain Barrier Opening in the Hippocampus of Alzheimer’s Double Transgenic Mice Using Pulsed Focused Ultrasound, Ultrasonic Imaging 30,  189-200, 2008.
  • Luo J., Fujikura K., Tyrie L.,  Tilson III M.D. and Konofagou E.E.., Pulse Wave Imaging of Normal and Aneurysmal Abdominal Aortas In Vivo, IEEE Trans. Med. Imag. 28, 477-486, 2009.
  • Vappou J., Maleke, C., and Konofagou, E.E., Quantitative viscoelastic parameters measured by Harmonic Motion Imaging, Phys. Med. Biol. 54(11):3579-94, 2009.
  • Luo J. and Konofagou E.E., Effects of Various Parameters on Lateral Displacement Estimation in Ultrasound Elastography, Ultras. Med. Biol. 35 (8), 1352–1366, 2009.
  • Luo J., Lee W-N, and Konofagou E.E., Fundamental Performance Assessment of 2-D Myocardial Elastography in a Phased Array Configuration, IEEE Trans. Ultras. Ferroel Freq. Control  56(10), 2620-2627, 2009.
  • Maleke C. and Konofagou E.E., In Vivo Feasibility of Harmonic Motion Imaging for Therapeutic Ultrasound, IEEE Trans. In Biomed. Eng. 57(1), 7-11, 2010.
  • Choi, J.J., Feshitan J., Wang S., Baseri B., Borden M., Konofagou, E.E., Microbubble-size dependence on focused ultrasound-induced blood-brain barrier opening in mice, IEEE Trans Biomed Eng 57(1), 145-154, 2010.
  • Choi, J.J., Wang S., Morrison B., Konofagou, E.E., Molecules of multiple pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo, Ultras. Med. Biol. 36 (1), 58–67, 2010.
  • Konofagou E.E., Luo J., Saluja D., Cervantes D., Coromilas J. and Fujikura K., Noninvasive electromechanical wave imaging and conduction-relevant velocity estimation in vivo, Ultrasonics 50, 208–215, 2010 [Invited].  NIHMS155400
  • Provost J., Lee W-N., Fujikura K., Wang J. and Konofagou E.E., Electromechanical Wave Imaging of Normal and Ischemic Hearts in Vivo, IEEE Trans. In Med. Imag. 29(3), 625-635, 2010.
  • Vappou J., Luo, J., and Konofagou, E.E., Pulse Wave Imaging for noninvasive and quantitative measurement of arterial stiffness, Amer. J. of Hypertens., 23(4),393-398, 2010.
  • Danpinid A., Luo J., Vappou J., Terdtoon P. and Konofagou E.E., Characterization of the Stress-Strain Relationship of the Abdominal Aortic Wall In Vivo, Ultrasonics, 50, 654–665, 2010.
  • Tung Y., Choi J., Baseri B. and Konofagou E.E., Identifying the Inertial Cavitation Threshold and Skull Effects in a Vessel Phantom Using Focused Ultrasound and Microbubbles, Ultras. Med. Biol. 36(5), 840-852, 2010.
  • Luo, J. and Konofagou, E.E., Fast Normalized Cross-Correlation Calculation with Exhaustive Search for Motion Estimation, IEEE-UFFC Trans. 57(6): 1347-1356, 2010.
  • Baseri B. Choi J., Tung Y., and Konofagou E.E., Multi-Modality Safety Assessment of Blood-Brain Barrier Opening Using Focused Ultrasound and Definity Microbubbles: A Short-Term Study, Ultras. Med. Biol. 36(9), 1445–1459, 2010.
  • Vlachos F., Tung Y.S. and Konofagou, E.E., Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI, Phys Med Biol  55, 5451-5466,2010.
  • Maleke, C., Luo J., Gamarnik V., Lu X. and Konofagou, E.E., Amplitude-modulated (AM) Harmonic Motion Imaging (HMI) - A Simulation Study with Experimental Validation, Ultrasonic Imaging, 32, 154-176, 2010.
  • Choi J., Selert K., Gao Z., Samiotaki G., Baseri B., and Konofagou E.E., Noninvasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies, Journal of Cerebral Flow and Metabolism, 31(2), 725-737, 2011.
  • Tung Y., Vlachos, F., Selert K. and Konofagou E.E., In vivo Transcranial Cavitation Threshold Detection during Ultrasound-Induced Blood-Brain Barrier Opening, Phys. Med. Biol, 55(20): 6141-6155, 2010.
  • Deffieux T and Konofagou, E.E., Numerical study and experimental validation of a simple transcranial focused ultrasound system applied to Blood-Brain Barrier Opening, IEEE-UFFC Trans. 57(12): 2637-53, 2010.
  • Marquet F, Tung Y-S, Konofagou E.E. Feasibility Study Of A Clinical Blood-Brain Opening Ultrasound System, Nano Life Vol. 1, Nos. 3 & 4, 309-322, 2010 [Invited].
  • Lee W-N, Provost J, Fujikura K, Wang J and Konofagou E.E.  In Vivo Validation of Strain Estimates at Variable Levels of Coronary Flow, Phys. Med. Biol. 56, 1155-1172, 2011. PMID:21285479
  • Tung Y., Marquet M., Teichert T., Ferrera V. and Konofagou E.E., Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates, Applied Physics Letters 98, 163704, 2011.
  • Provost J, Gurev V, Trayanova N., and Konofagou E.E., Mapping of Cardiac Electrical Activation with Electromechanical Wave Imaging: An in silico-in vivo Reciprocity Study 8(5):752-9, Heart Rhythm, 2011. PMC3100212
  • Konofagou, E.E., Maleke, C., and Vappou J., Harmonic Motion Imaging (HMI) for Tumor Imaging and Treatment Monitoring, Current Medical Imaging Reviews (CMIR), 477-506, 2011.
  • Vlachos F., Tung Y.S., Feshitan J., Borden, M.A. and Konofagou, E.E., Quantitative permeability assessment of the focused ultrasound-induced blood-brain barrier opening using DCE-MRI, Magnetic Resonance in Medicine, 66(3):821-30,2011.
  • Luo J and Konofagou E.E., Simultaneous Imaging of Wall Motion and Blood Flow Velocity in the Heart and Vessels in vivo: A Feasibility Study, Ultras. Med. Biol. 37(6):980-95,2011.
  • Vappou J., Luo, J., Okajima K. and Konofagou, E.E., Aortic Pulse Wave Velocity Measured By Pulse Wave Imaging (PWI): A Comparison With Applanation Tonometry, Artery Research, Artery Research 5(2): 65-71, 2011.
  • Provost J, Lee W-N, Fujikura K, and Konofagou E.E., Imaging the Electromechanical Activity of the Heart In Vivo, Proc. Nat.Acad. Sci, 108(21):8565-70, 2011. PMC3102378
  • Konofagou E.E, Lee W-N, Luo, J., Provost J, and Vappou J., Physiologic Cardiovascular Strain and Intrinsic Wave Imaging, Annu. Rev. Biomed. Eng. 13:477–505, 2011.
  • Langevin H M, Fox J R, Koptiuch C, Badger GJ, Greenan-Naumann AC, Bouffard NA, Konofagou EE, Lee W-N, Triano JJ and Henry SM.Reduced thoracolumbar fascia shear strain in human chronic low back pain, BMC Musculoskeletal Disorders, BMC Musculoskeletal Disorders 12:203, 2011.
  • Vappou, J., Luo, J., Okajima K., Di Tullio M. and Konofagou, E. J. Non-Invasive Measurement of Local Pulse Pressure by Pulse-Wave-based Ultrasound Manometry (PWUM) Physiol. Meas., 2010, Vol. 32(10), pp. 1653-62, 2011.
  • Feshitan JA, Vlachos F, Sirsi SR, Konofagou EE, Borden MA. Theranostic Gd(III)-lipid microbubbles for MRI-guided focused ultrasound surgery. Biomaterials. 2011 Oct 10. [Epub ahead of print]
  • Marquet F, Tung Y-S, Teichert T., Ferrera V., Konofagou E.E. Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo, PLoS One 6(7):e225982011, 2011.
  • Choi J., Selert K., Vlachos F., Wong A., and Konofagou E.E., Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles, Proceedings of the National Academy of Sciences (PNAS) 108(40), 16539-16544, 2011.
  • Tung, Y-S, Vlachos F., Feshitan J., Borden M.A., Konofagou E.E.  The Mechanism Of The Interaction Between Focused Ultrasound And Microbubbles In Blood-Brain Barrier Opening In Mice, J. Acous. Soc. Amer 108(40), 130 (5), 3059-3067, 2011.
  • Provost J, Nguyen VT, Legrand D, Okrasinski S, Costet A, Gambhir A, Garan H, Konofagou EE., Electromechanical wave imaging for arrhythmias, Phys Med Biol. Nov 21;56(22):L1-11, 2011.
  • Feshitan JA, Vlachos F, Sirsi SR, Konofagou EE, Borden MA. Theranostic Gd(III)-lipid microbubbles for MRI-guided focused ultrasound surgery. Biomaterials. 33(1):247-55, 2012.
  • Samiotaki, M, Vlachos F., Tung Y-S, Feshitan J., Borden M, Konofagou E.E. A Quantitative Pressure and Microbubble-Size Dependence Study of Focused Ultrasound-Induced Blood-Brain Barrier Opening Reversibility In Vivo Using MRI, , Magn Reson Med. Magn Reson Med. Mar;67(3):769-77. 2012. PMC3658823
  • Hou Y., Luo, J., Marquet F., Maleke C., Vappou J., Konofagou E.E.  Performance Assessment Of HIFU Lesion Detection By Harmonic Motion Imaging For Focused Ultrasound (HMIFU): A 3-D Finite-Element-Based Framework With Experimental Validation, Ultras. Med. Biol., 2012.
  • Luo J., Li R. and Konofagou E.E., Pulse Wave Imaging (PWI) of the Human Carotid Artery: An In Vivo Feasibility Study, IEEE Trans. Ultras. Ferroel. Freq Control,;59(1):174-81, 2012.
  • Khamdaeng T., Luo J., Vappou J., Terdtoon P., Konofagou E.E., Arterial stiffness identification of the human carotid artery using the stress–strain relationship in vivo, Ultrasonics, 52(3): 402-411, 2012.
  • Konofagou, E.E. and Provost J., Electromechanical Wave Imaging for Noninvasive Mapping of the 3D Electrical Activation Sequence in Canines and Humans in vivo, J. Biomech. 15;45(5):856-64, 2012 [Invited]. NIHMS353135
  • Provost J. Thiebault S., Luo J. and Konofagou, E.E. and Single-heartbeat electromechanical wave imaging with optimal strain estimation using temporally unequispaced acquisition sequences, Phys Med Biol, 57(4):1095-112, 2012. NIHMS375306
  • Baseri B., Choi J.J., Deffieux T., Samiotaki G., Tung Y-S.,Olumolade O., Small, S.A., Morrison B. III, Konofagou E.E., Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles, Phys. Med. Biol. 57, N65–N81, 2012. NIHMS375337
  • Hariharan, V., Provost, J., Shah, S., Konofagou, E.E., and Huang, H. Elevated Strain and Structural Disarray Occur at the Right Ventricular Apex, Cardiovascular Engineering and Technology, rdiovascular Engineering and Technology, Volume 3, Issue 1, pp 52-61, 2012.
  • Maidhof R, Tandon N, Lee EJ, Luo J, Duan Y, Yeager K, Konofagou E, Vunjak-Novakovic G.Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue. J Tissue Eng Regen Med. Nov;6(10):e12-23, 2012.
  • Shahmirzadi D, Konofagou EE. Detection of Aortic Wall Inclusion Using Regional Pulse Wave Propagation and Velocity In Silico. Artery Research, 5(2): 65-71, 2012. NIHMS382500
  • Okrasinski SJ, Ramachandran B, Konofagou E.E. Assessment of myocardial elastography performance in phantoms under combined physiologic motion configurations with preliminary in vivo feasibility, Phys. Med. Biol., 7;57(17):5633-50, 2012.
  • Katouzian A, Karamalis A, Sheet D, Konofagou EE, Baseri B, Carlier SG, Eslami A, König A, Navab N, Laine AF. Iterative self-organizing atherosclerotic tissue labeling in intravascular ultrasound images and comparison with virtual histology. IEEE Trans Biomed Eng. 59(11):3039-49, 2012.
  • Konofagou EE, Tung YS, Choi J, Deffieux T, Baseri B, Vlachos F. "Ultrasound-induced blood-brain barrier opening." Curr Pharm Biotechnol. 2012 Jun;13(7):1332-45. Review. PMID: 22201586 [Invited]
  • Konofagou EE.. "Optimization of the ultrasound-induced blood-brain barrier opening." Theranostics. 2012; 2(12):1223-37. PMID: 23382778 [Invited]
  • Shahmirzadi D, Konofagou EE. Pulse-Wave Propagation in Straight-Geometry Vessels for Stiffness Estimation: Theory, Simulations, Phantoms and In Vitro Findings, J. Biomech Eng., 134(11): 114502, 2012.
  • Marsano A, Maidhof R, Luo J, Fujikura K, Konofagou EE, Banfi A, Vunjak-Novakovic G. The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction. Biomaterials. 34(2):393-401, 2013. PMC3490044
  • Chen C, Wu, SY, Finan, J, Morrison III, B. and Konofagou EE. An Experimental Study on the Stiffness of Size-Isolated Microbubbles Using Atomic Force Microscopy, IEEE Trans. Ultras. Ferroel. Freq. Control, 60 (3), 524-534, 2013.
  • Provost J., Gambhir A., Garan H. and Konofagou E.E., A Clinical Feasibility Study of Atrial and Ventricular Electromechanical Wave Imaging, Heart Rhythm 10(6), 856-862, 2013.
  • Li R., Luo J., Balaram S., Chaudhry F., Lantis J., Shahmirzadi D. and Konofagou EE, Pulse wave imaging in normal, hypertensive and aneurysmal human aortas in vivo: a feasibility study, Phys. Med. Biol. 58, 4549-4562, 2013.
  • Shahmirzadi D, Narayanan P, Li RX, Qaqish WW and Konofagou EE, Mapping the longitudinal wall stiffness heterogeneities within intact canine aortas using Pulse Wave Imaging (PWI) ex vivo, J. Biomech 46(11), 1866-1874, 2013.
  • Shahmirzadi D, Hou Y, Chen J., and Konofagou EE, Ex Vivo Characterization Of Canine Liver Tissue Viscoelasticity After High-Intensity Focused Ultrasound Ablation, Ultras. Med. Biol., 2013.
  • Samiotaki, G. and Konofagou, E, Dependence of the Reversibility of Focused-Ultrasound Induced Blood-Brain Barrier Opening on Pressure and Pulse Length, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Volume 60, Number 11, Pages 2257-2265, November 2013.
  • Chen C.C., Sheeran P. S., Wu S.Y, Olumolade O. O., Dayton P. S., Konofagou, E. Targeted Drug Delivery with Focused Ultrasound-induced Blood-Brain Barrier Opening using Acoustically-activated Nanodroplets, J. Cont. Release, Volume 172, Number 3, Pages 795-804, 2013.
  • Alexandre Costet, Jean Provost, Alok Gambhir, Yevgeniy Bobkov, Peter Danilo Jr., Gerard J. J. Boink, Michael R. Rosen, Elisa E. Konofagou, Electromechanical Wave Imaging of Biologically And Electrically Paced Canine Hearts In Vivo, Ultrasound in Medicine and Biology, Volume 40, Number 1, Pages 177-187, January 2014
  • Wang S., Samiotaki, G. and Konofagou, E, Microbubble Type and Distribution Dependence of Focused Ultrasound Induced Blood Brain Barrier Opening, Ultrasound Med Biol. Volume 40, Number 1, Pages 130-137, January 2014
  • Fabrice Marquet, Tobias Teichert, Shih-Ying Wu, Yao-Sheng Tung, Matthew E. Downs, Shutao Wang, Cherry C. Chen, Vincent P. Ferrera, Elisa E. Konofagou, Real-Time, Transcranial Monitoring of Safe Blood-Brain Barrier Opening in Non-Human Primates, PLoS One, Volume 9, Number 2, February 2014
  • Yi Hou, Fabrice Marquet, Shutao Wang, Elisa E. Konofagou,Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study, Physics in Medicine and Biology, Volume 59, Pages 1121-1145, February 2014
  • Danial Shahmirzadi, Yi Hou, Jiangang Chen, Elisa E. Konofagou, Ex Vivo Characterization of Canine Liver Tissue Viscoelasticity After High-Intensity Focused Ultrasound Ablation, Ultrasound in Medicine and Biology, 2014
  • Shih-Ying Wu, Yao-Sheng Tung, Fabrice Marquet, Matthew E. Downs, Carlos J. Sierra Sánchez, Cherry C. Chen, Vincent P. Ferrera, Elisa E. Konofagou, Transcranial Cavitation Detection in Primates during Blood-Brain Barrier Opening - A Performance Assessment Study, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2014 Jun;61(6):966-78.
  • Chen H. and Konofagou E.E., The size of BBB opening induced by FUS is dictated by the acoustic pressure, J. Cereb. Flow and Metab., 2014 Jul;34(7):1197-204.
  • Nandlall SD, Goldklang MP, Kalashian A, Dangra NA, D'Armiento JM, Konofagou EE. Monitoring and staging abdominal aortic aneurysm disease with pulse wave imaging. Ultrasound Med Biol. 2014 Oct;40(10):2404-14.
  • Hou G, Provost J, Grondin J, Wang S, Marquet F, Bunting E, Konofagou E. Sparse matrix beamforming and image reconstruction for real-time 2D HIFU monitoring using Harmonic Motion Imaging for Focused Ultrasound (HMIFU) with in vitro validation. IEEE Trans Med Imaging. 2014 Jun 20.
  • Shahmirzadi D, Konofagou EE. Quantification of Arterial Wall Inhomogeneity Size, Distribution, and Modulus Contrast Using FSI Numerical Pulse Wave Propagation. Artery Res. 2014 Jun 1;8(2):57-65.
  • Wang S, Olumolade O, Sun T, Samiotaki G, Konofagou EE. Non-invasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus, Gene Therapy (in press).
  • Sacha D. Nandlall, Monica P. Goldklang, Aubrey Kalashian, Nida A. Dangra, Jeanine M. d'Armiento, Elisa E. Konofagou, Monitoring and staging abdominal aortic aneurysm disease with pulse wave imaging, Ultrasound in Medicine and Biology, Volume 40, Number 10, Pages 2404-2414, October 2014.
  • Yi Hou, Jean Provost, Julien L. Grondin, Shutao Wang, Fabrice Marquet, Ethan A. Bunting, Elisa E. Konofagou, IEEE Transactions on Medical Imaging, Volume 33, Number 11, Pages 2107-2117, November 2014.
  • Bunting, E, Provost J., and Konofagou EE, Performance Analysis of Two-Dimensional Cardiac Strain Estimation Using Novel SequencesDifferent Beamforming and Temporal Resolution in Vivo, Phys. Med. Biol. 2014 (in press).
  • Grondin J, Konofagou EE, Intracardiac Myocardial Elastography in vivo, IEEE Trans. Ultras. Ferroel. Freq. Control, Volume 62, Number 2, Pages 337-349,2015.
  • Danial Shahmirzadi, Yi Hou, Jiangang Chen, Elisa E. Konofagou, Ex Vivo Characterization of Canine Liver Tissue Viscoelasticity After High-Intensity Focused Ultrasound Ablation, Ultrasound in Medicine and Biology (in press).


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