Barclay Morrison

Professor of Biomedical Engineering
Vice Dean of Undergraduate Programs, Fu Foundation School of Engineering and Applied Science

351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904
New York , NY 10027

Phone: +1 212-854-6277
Fax: +1 212-854-8725
Email: bm2119@columbia.edu
CV

Research Areas:

Mechanical injury of the central nervous system:1) improvement of prevention strategies through development of critical biomechanical data for the living brain, 2) identification of novel treatment options by understanding the post-traumatic pathobiology in greater detail, 3) engineering new research tools to enhance studies in the first two areas.

Neurotrauma and Repair Laboratory

Education

  • 1988-92: B.S.E., Biomedical Engineering, Johns Hopkins University, Baltimore, MD
  • 1992-94: M.S.E., Bioengineering, University of Pennsylvania, Philadelphia, PA
  • 1994-99: Ph.D., Bioengineering, University of Pennsylvania, Philadelphia, PA
  • 1999: Postdoctoral, Traumatic Brain Injury, University of Pennsylvania, Philadelphia, PA
  • 2000-1: Postdoctoral, Head Injury/Ischemia, University of Southampton, United Kingdom
  • 2001-2: Postdoctoral, Traumatic Brain Injury, University of Southampton, United Kingdom

Professional Experience

  • 1994: Teaching Assistant, Department of Bioengineering, University of Pennsylvania
  • 1994-99: Research Fellow, Department of Bioengineering, University of Pennsylvania
  • 1998: Teaching Assistant, Department of Bioengineering, University of Pennsylvania
  • 1999-2000: Postdoctoral Fellow, Department of Neurosurgery, University of Pennsylvania
  • 2000-2002: Postdoctoral Fellow, Division of Clinical Neurosciences, University of Southampton
  • 2003-2016 : Assistant Professor, Department of Biomedical Engineering, Columbia University
  • 2016- : Professor, Department of Biomedical Engineering, Columbia University

Honors

  • 1993-97: Ashton Fellowship, University of Pennsylvania
  • 1999: The S.R. Pollack Award for Excellence in Graduate Bioengineering Research, University of Pennsylvania
  • 1999: Biomedical Engineering Society Graduate Student Research Award
  • 1999: First Place, National Neurotrauma Society Student Competition
  • 1999: Biomedical Engineering Society Travel Award
  • 1999: National Neurotrauma Society Travel Award
  • 2001: Richard Skalak Best Paper Award in the Journal of Biomechanical Engineering for 2000, Bioengineering Division of the American Society of Mechanical Engineers
  • 2004: John Paul Stapp Best Paper Award in the Stapp Car Crash Journal for 2003
  • 2006: The Kim Award for Student-Faculty Involvement, Fu Foundation School of Engineering and Applied Science, Columbia University
  • 2009: Keynote speaker, annual meeting of the International Research Council on Biomechanics of Injury
  • 2010: Invited speaker, annual National Neurotrauma Symposium
  • 2013: Cover image, Journal of Neurotrauma for Hue, C.D., Cao, S., Haider, S.F., Vo, K. V., Effgen, G.B., Vogel, E.W., Panzer, M.B., Bass, C.R., Meaney, D.F., Morrison III, B.Blood-brain barrier dysfunction after primary blast injury in vitro, J. Neurotrauma, 2013, 30: 1652-1663.
  • 2015: Elected Vice President of the International Research Council on Biomechanics of Injury

Full-Length Manuscripts

Morrison III, B., Meaney, D.F., and McIntosh, T.K., Mechanical characterization of an in vitro device to quantitatively injure living brain tissue. Ann.Biomed.Eng., 1998. 26: p. 381-90.

Morrison III, B., Saatman, K.E., Meaney, D.F., and McIntosh, T.K., In vitro central nervous system models of mechanically induced trauma: A review. J.Neurotrauma, 1998. 15: p. 911-28.

O'Dell, D.M., Raghupathi, R., Crino, P.B., Morrison III, B., Eberwine, J.H., and McIntosh, T.K., Amplification of mRNAs from single, fixed, TUNEL-positive cells. BioTechniques, 1998. 25: p. 566-8.

Morrison III, B., Eberwine, J.H., Meaney, D.F., and McIntosh, T.K., Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. Neurosci., 2000. 96: p. 131-9.

Morrison III, B., Meaney, D.F., Margulies, S.S., and McIntosh, T.K., Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: Relationship to mechanical parameters. J.Biomech.Eng., 2000. 122: p. 224-30. (Best Paper Award in the journal for that year)

Morrison III, B., Pringle, A.K., McManus, T., Ellard, J., Bradley, M., Signorelli, F., Iannotti, F., and Sundstrom, L.E., L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission. Brit.J.Pharm., 2002. 137: p. 1255-68.

Cater, H.L., Chandratheva, A., Benham, C.D., Morrison III, B., and Sundstrom, L.E., Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. J.Neurochem., 2003. 87: p. 1381-90.

Morrison III, B., Cater, H.L., Wang, C.B., Thomas, F.C., Hung, C.T., Ateshian, G.A., and Sundstrom, L.E., A tissue level tolerance criteria for living brain developed with an

Barclay Morrison III Curriculum Vitae 14 of 52 in vitro model of traumatic mechanical loading. Stapp Car Crash J., 2003. 47: p. 93-105. (Best paper award in the journal for that year)

Pringle, A.K., Morrison III, B., Bradley, M., Iannotti, F., and Sundstrom, L.E., Characterisation of a novel class of polyamine-based neuroprotective compounds Naunyn-Schmiedeberg's Arch.Pharm., 2003. 368: p. 216-24.

Sundstrom, L., Morrison III, B., Bradley, M., and Pringle, A., Organotypic cultures as tools for functional screening in the CNS. Drug Discov.Today, 2005. 10: p. 993-1000.

Cater, H.L., Sundstrom, L.E., and Morrison III, B., Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J.Biomech., 2006. 39: p. 2810-8.

Morrison III, B., Cater, H.L., Benham, C.D., and Sundstrom, L.E., An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. J.Neurosci.Meth., 2006. 150: p. 192-201.

Cater, H.L., Gitterman, D.P., Davis, S.M., Benham, C.D., Morrison III, B., and Sundstrom, L.E., Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: Role of glutamate receptors and voltage-dependent calcium channels. J.Neurochem., 2007. 101: p. 434-47.

Elkin, B.S., Azeloglu, E.U., Costa, K.D., and Morrison III, B., Mechanical heterogeneity of the rat hippocampus measured by AFM indentation. J.Neurotrauma, 2007. 24: p. 812-22.

Elkin, B.S. and Morrison III, B., Region-specific tolerance criteria for the living brain. Stapp Car Crash J., 2007. 51: p. 127-38.

Yu, Z., McKnight, T.E., Ericson, M.N., Melechko, A.V., Simpson, M.L., and Morrison III, B., Vertically aligned carbon nanofiber arrays record electrophysiological signals from hippocampal slices. Nano Lett., 2007. 7: p. 2188-95.

Ateshian, G.A., Costa, K.D., Azeloglu, E.U., Morrison III, B., and Hung, C.T., Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density. J.Biomech.Eng., 2009. 131: p. 101001.

Gao, S., Simon, M.J., Morrison III, B., and Banta, S., Bifunctional chimeric fusion proteins engineered for DNA delivery: Optimization of the protein to DNA ratio. Biochim.Biophys.Acta, 2009. 1790: p. 198-207.

Graudejus, O., Yu, Z., Jones, J., Morrison III, B., and Wagner, S., Characterization and application of an elastically stretchable microelectrode array to neural field potential recordings. J.Electrochem.Soc., 2009. 156: p. P85-P94.

Margulies, S.S., Hicks, R.R., Ansel, B., Bullock, R., Clifford, D., Clifton, G., Conwit, R., Dash, P., Diaz-Arrastia, R., Dietrich, W.D., et al., Combination therapies for traumatic brain injury - prospective considerations. J.Neurotrauma, 2009. 26: p. 925-39.

Simon, M.J., Gao, S., Banta, S., and Morrison III, B., TAT-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression. Biotechnology and Bioengineering, 2009. 104: p. 10-9.

Yu, Z., Graudejus, O., Tsay, C., Lacour, S.P., Wagner, S., and Morrison III, B., Monitoring electrical activity from hippocampal tissue during large electrode deformation. J.Neurotrauma, 2009. 26: p. 1135-45.

Ateshian, G.A., Morrison III, B., and Hung, C.T., Modeling of active transmembrane transport in a mixture theory framework. Ann.Biomed.Eng., 2010. 38: p. 1801-14.

Choi, J.J., Wang, S., Tung, Y.S., Morrison III, B., and Konofagou, E.E., Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med.Biol., 2010. 36: p. 58-67.

Elkin, B.S., Ilankovan, A., and Morrison III, B., Age-dependent regional mechanical properties of the rat hippocampus and cortex. J.Biomech.Eng., 2010. 132.

Elkin, B.S., Shaik, M.A., and Morrison III, B., Fixed negative charge and the Donnan effect: A description of the driving forces associated with brain tissue swelling and edema. Phil.Trans.Royal Soc.London A, 2010. 368: p. 585-603.

Gao, S., Simon, M.J., Morrison III, B., and Banta, S., A plasmid display platform for the selection of peptides exhibiting a functional cell penetrating phenotype. Biotech.Prog., 2010. 26: p. 1796-1800.

Lacour, S.P., Benmerah, S., Tarte, E., FitzGerald, J., Serra, J., McMahon, S., Fawcett, J.W., Graudejus, O., Yu, Z., and Morrison III, B., Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces. Med.Biol.Eng.Comp., 2010. 48: p. 945-954.

Li, G., Simon, M.J., Cancel, L., Shi, Z., Ji, X., Tarbell, J.M., Morrison III, B., and Fu, B.M., Permeability of endothelial and astrocyte cocultures: In vitro blood-brain barrier models for drug delivery studies. Ann.Biomed.Eng., 2010. 38: p. 2499-511.

Simon, M.J., Kang, W.H., Gao, S., Banta, S., and Morrison III, B., Increased delivery of TAT across an endothelial monolayer folowing ischemic injury. Neurosci.Lett., 2010, 486: 1-4.

Yu, Z. and Morrison III, B., Experimental mild traumatic brain injury induces functional alteration of the developing hippocampus. J.Neurophysiol, 2010. 103: p. 499- 510.

Simon, M.J., Kang, W.H., Gao, S., Banta, S., and Morrison III, B., TAT is not capable of transcellular delivery across an intact endothelial monolayer in vitro. Ann.Biomed.Eng., 2011 39: p.394-401.

Elkin, B.S., Ilankovan, A., and Morrison III, B., A detailed viscoelastic characterization of the P17 and adult rat brain. J.Neurotrauma, 2011, 28: p.2235-2244.

Elkin, B.S., Shaik, M.A., and Morrison III, B., Chondroitinase ABC reduces brain tissue swelling in vitro. J.Neurotrauma, 2011, 28: p.2277-2285.

Gao, S., Simon, M.J., Morrison III, B., and Banta, S., An unusual cell penetrating peptide identified using a plasmid display-based functional selection platform. ACS Chem.Bio., 2011 6: p.484-91.

Morrison III, B., Elkin, B.S., Dolle, J.P., Yarmush, M.L., In vitro models of traumatic brain injury. Ann.Rev.Biomed.Engin., 2011, 13: p.91-126.

Kang, W.H., Simon, M.J., Gao, S., Banta, S., and Morrison III, B., Attenuation of astrocyte activation by TAT delivery of a peptide JNK inhibitor. J.Neurotrauma, 2011, 28: 1219-1228.

Elkin, B.S., Ilankovan, I., Morrison III, B., Dynamic, regional mechanical properties of the porcine brain: Indentation in the coronal plane. J.Biomech.Eng., 2011, 133: 071009.

Finan, J.D., Elkin, B.S., Pearson, E.M., Kalbian I.L., Morrison III, B., Viscoelastic properties of the rat brain in the sagittal plane: effects of anatomical structure and age. Ann.Biomed.Eng., 2012, 40: 70-78..

 Graudejus, O., Goletiani, C., Yu, Z., Morrison III, B., and Wagner, S., Encapsulating elastically stretchable neural interfaces: yield, resolution,and recording/stimulation of neural activity. Advanced Functional Materials, 2012, 22: 640- 651.

Saggu, R., Morrison III, B., Lowe, J.P., Pringle, A.K., Interleukin-1b does not affect the energy metabolism of rat organotypic hippocampal-slice cultures. Neuroecience Letters, 2012, 508: 114-118.

Ateshian, G.A., Morrison III, B., Holmes, J.W., and Hung, C.T., Mechanics of cell growth. Mechanics Research Communications, 2012, 42: 118-125.

Baseri, B., Choi, J.J., Deffieux, T., Samiotaki, M., Tung, Y., Small, S.A., Morrison III, B., and Konofagou, E.E., Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles. Phys.Med.Biol., 2012, 57: N65-N81.

Effgen, G.B., Hue, C.D., Vogel, E.W., Panzer, M.B., Meaney, D.F., Bass, C.R., Morrison III, B., A multiscale approach to blast neurotrauma modeling: Part II: Methodology for inducing blast injury to in vitro models, Frontiers in Neurology, 2012, 3: 10.3389/fneur.2012.00023.

Yu, Z., McKnight, T.E., Ericson, M.N., Melechko, A.V., Simpson, M.L., Morrison III, B., Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function, Nanomedicine: Nanotechnology, Biology, and Medicine, 2012, 8: 419-423.

Panzer, M.B., Matthews, K.A., Yu, A.W., Morrison III, B., Meaney, D.F., Bass, C.R., A multiscale approach to blast neurotrauma modeling: Part I: Development of novel test devices for in vivo and in vitro blast injury models, Frontiers in Neurology, 2012, 3:46. doi: 10.3389/fneur.2012.00046.

Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., Skouta, R., Zaitsev, E., Gleason, C.E., Patel, D., Bauer, A.J., Cantley, A., Yang, W.S., Morrison III, B., Stockwell, B.R., Ferroptosis: an iron-dependent oncogenic-RAS-selective form of cell death, Cell, 2012, 149:1060-1072.

Choo, A.M., Miller, W.J., Chen, Y., Nibley, P., Goletiani, C., Morrison III, B., Kutzing, M.K., Firestein, B.L., Sul, J.Y., Haydon, P.G., Meaney, D.F., Antagonism of astroglial purinergic signaling improves recovery from traumatic brain injury, Brain, 2013, 136: 65-80.

Chen, C., Wu, S., Finan, J.D., Morrison III, B., and Konofagou, E.E., An experimental study on the stiffness of size-isolated microbubbles using atomic force microscopy, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2013, 60: 524-534.

Dolle, J.P., Morrison III, B., Schloss, R.S., and Yarmush, M.L., An organotypic uniaxial strain model using microfluidics, Lab Chip, 2013, 13: 432-42.

Mao, H., Elkin, B.S., Genthikatti, V.V., Morrison III, B., Yang, K.H., Why is CA3 more vulnerable than CA1 in experimental models of controlled cortical impact-induced brain injury?, J. Neurotrauma, 2013, 30: 1521-1530.

Hue, C.D., Cao, S., Haider, S.F., Vo, K. V., Effgen, G.B., Vogel, E.W., Panzer, M.B., Bass, C.R., Meaney, D.F., Morrison III, B., Blood-brain barrier dysfunction after primary blast injury in vitro, J. Neurotrauma, 2013, 30: 1652-1663.

Elkin, B.S., Morrison III, B., Viscoelastic properties of the P17 and adult rat brain in the coronal plane, J.Biomech.Eng., 2013, 135: 114507.

Dolle, J.P., Morrison III, B., Schloss, R.S., and Yarmush, M.L., Brain-on-a-chip microsystem for investigating traumatic brain injury: Axon diameter and mitochondrial membrane changes play a significant role in axonal response to strain injuries. Technology (Singapore), 2014. 2: 106.

Effgen, G.B., Vogel, E.W., Lynch, K.A., Lobel, A., Hue, C.D., Meaney, D.F., Bass, C.R., and Morrison III, B., Isolated primary blast alters electrophysiological function with minimal cell death in organotypic hippocampal slice cultures, J.Neurotrauma, 2014 31: 1202-10.

Finan, J.D., Fox, P.M., Morrison III, B., Non-ideal effects in indentation testing of soft tissues, Biomech. Model. Mechanobiol., 2014, 13: 573-84.

Gullotti, D., Panzer, M., Beamer, M., Chen, Y.C., Patel, T., Yu, A., Jaumard, N., Winkelstein, B., Bass, C.R., Morrison III, B., and Meaney, D.F., Significant head accelerations can influence immediate neurological impairments in a murine model of blast-induced traumatic brain injury. J.Biomech.Eng. 2014, 136: 091004.

Hue, C.D., Cao, S., Bass, C.R., Meaney, D.F., and Morrison III, B., Repeated primary blast injury causes delayed recovery, but not additive disruption, in an in vitro blood-brain barrier model. J.Neurotrauma, 2014, 31: 951-60.

Hughes, R.H., Silva, V.A., Ahmed, I., Shreiber, D.I., Morrison III, B., Neuroprotection by genipin against reactive oxygen and reactive nitrogen speciesmediated injury in organotypic hippocampal slice cultures, Brain Res., 2014, 1543: 308- 314.

Lamprecht, M.R. and Morrison III, B., GPR30 activation is neither necessary nor sufficient for acute neuroprotection by 17β-estradiol after an ischemic injury in organotypic hippocampal slice cultures, Brain Res., 2014, 1563: 131-7.

Meaney, D.F., Morrison III, B., and Bass, C.R., The mechanics of traumatic brain injury: A review of what we know, and what we need to know, for reducing its societal burden. J.Biomechanical Eng., 2014, 136: 021008.

Patel, T.P., Gullotti, D.M., Hernandez, P., O'Brien, W.T., Capehart, B.P., Morrison III, B., Bass, C.R., Eberwine, J.E., Abel, T., and Meaney, D.F., An open-source toolbox for automated phenotyping of mice in behavioral tasks, Front.Behav.Neurosci., 2014, 8: 349, doi: 10.3389/fnbeh.2014.00349.

Kang, W.H. and Morrison III, B., Functional tolerance to mechanical deformation developed from organotypic hippocampal slice cultures, Biomech.Model.Mechanobiol., 2015, 14: 561-75.

Kang, W.H., Cao, W., Graudejus, O., Patel, T.P., Wagner, S., Meaney, D.F., and Morrison III, B., Alterations in hippocampal network activity after in vitro traumatic brain injury, J.Neurotrauma., 2015, 32: 1011-9.

Kang, W.H. and Morrison III, B., Predicting changes in cortical electrophysiological function after in vitro traumatic brain injury, Biomech.Model.Mechanobiol., 2015, 14: 1033-44.

Lamprecht, M.R. and Morrison III, B., A combination therapy of 17β-estradiol and memantine is more neuroprotective than monotherapies in an organotypic brain slice culture model of traumatic brain injury, in J.Neurotrauma, 2015, 32: 1361-8.

Hue, C.D., Cho, F.S., Cao, S., Bass, C.R., Meaney, D.F., and Morrison III, B., Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast

Barclay Morrison III Curriculum Vitae 18 of 52 injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein. J.Cerebral Blood Flow & Metab., 2015, 35: 1191-8.

Finan, J.D., Cho, F.S., Kernie, S.G., Morrison III, B. Intracerebroventricular administration of chondroitinase ABC reduces acute edema after traumatic brain injury. BMC Research Notes, 2016, 9: 160.

Effgen, G.B., Ong, T., Nammalwar, S., Ortuno, A.I., Meaney, D.F., Bass, C.R., Morrison III, B. Primary blast exposure increases hippocampal vulnerability to subsequent exposure reducing long-term potentiation. J.Neurotrauma. in press.

Hue, C.D., Cho, F.S., Cao, S., Nicholls, R.E., Vogel III, E.W., Sibindi C., Arancio O., Bass C.R., Meaney D.F., Morrison III B. Time course and size of blood-brain barrier opening in a mouse model of blast-induced traumatic brain injury. J.Neurotrauma. in press.

Lamprecht, M.R., Elkin, B.S., Kesavabhotla, K., Crary, J.F., Raghupathi, R., Morrison III, B. Correlation of genome-wide expression after traumatic brain injury in vitro and in vivo implicates a role for SORLA. J.Neurotrauma. in press.

Vogel III, E.W., Effgen, G.B., Patel, T.P., Meaney, D.F., Bass, C.R., Morrison III, B. Isolated primary blast inhibits long-term potentiation in organotypic hippocampal slice cultures. J.Neurotrauma, 2016, 33:652-61.

Effgen, G.B. and Morrison III, B., Electrophysiological and pathological characterization of the period of heightened vulnerability to repetitive injury in an in vitro stretch model, J.Neurotrauma. in press.

Beamer, M., Tummala, S., Gullotti, D., Kopil, K., Gorka, S., Abel, T., Bass, C.R., Morrison III, B., Cohen, A.S., and Meaney, D.F., Primary blast injury causes cognitive impairments and hippocampal circuit alterations, Experimental Neurology. in press.

Effgen, G.B. and Morrison III, B., Memantine reduced cell death, astrogliosis, and functional deficits in an in vitro model of repetitive mild traumatic brain injury. J.Neurotrauma. in press.

Vogel III, E.W., Rwema, S.H., Meaney, D.F., Bass, C.R., Morrison III, B. Primary blast injury depressed hippocampal long-term potentiation through disruption of synaptic proteins, J. Neurotrauma. in press.

Mechanical injury of the central nervous system: 1) universal tissue tolerance criteria, 2) role of the cytoskeleton in injury, 3) application of genomic and proteomic technologies to mechanotransduction, 4) repair strategies using stem cells, 5) electrode design for neural engineering.


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